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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2010 Volume 23 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Association of the ABCB1 3435C>T polymorphism and treatment outcomes in advanced gastric cancer patients treated with paclitaxel-based chemotherapy

  • Authors:
    • Hyun Chang
    • Sun Young Rha
    • Hei-Cheul Jeung
    • Chong Kun Im
    • Sung Hoon Noh
    • Jin Ju Kim
    • Hyun Cheol Chung

  • View Affiliations / Copyright

    Affiliations: Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
  • Pages: 271-278
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/or_00000633
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Abstract

We evaluated the frequency of ABCB1 polymorphisms (2677G/T>A and 3435C>T) and studied the association between the polymorphisms and clinical outcomes of paclitaxel-based chemotherapy in advanced gastric cancer patients. This study was performed in 43 gastric cancer patients and a control group consisting of 118 healthy volunteers. Patients were treated with paclitaxel combined with an infusional 5-fluorouracil and low-dose leucovorin. Genomic DNA from peripheral blood mononuclear cells was used to determine ABCB1 polymorphisms by direct sequencing. Genotypes were investigated for their association with survival and toxicity. The ABCB1 3435 C allele was more frequent in gastric cancer patients than healthy volunteers (p<0.001). The 2677G>T/A and 3435C>T polymorphisms were independent factors associated with shorter progression-free survival (PFS) (p=0.024, p=0.001, respectively). In combined analysis of 2677 and 3435 polymorphisms, the 3435C>T polymorphism was an independent factor for poor PFS (p=0.01). The 3435CT and TT genotypes were associated with mucositis (p=0.04), and the variant genotypes at 2677 loci were associated with diarrhea (p=0.034). Our data suggest that the ABCB1 polymorphism at 3435 is associated with clinical outcomes after paclitaxel-based combined chemotherapy in advanced gastric cancer patients.

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Copy and paste a formatted citation
Spandidos Publications style
Chang H, Rha SY, Jeung H, Im CK, Noh SH, Kim JJ and Chung HC: Association of the ABCB1 3435C>T polymorphism and treatment outcomes in advanced gastric cancer patients treated with paclitaxel-based chemotherapy. Oncol Rep 23: 271-278, 2010.
APA
Chang, H., Rha, S.Y., Jeung, H., Im, C.K., Noh, S.H., Kim, J.J., & Chung, H.C. (2010). Association of the ABCB1 3435C>T polymorphism and treatment outcomes in advanced gastric cancer patients treated with paclitaxel-based chemotherapy. Oncology Reports, 23, 271-278. https://doi.org/10.3892/or_00000633
MLA
Chang, H., Rha, S. Y., Jeung, H., Im, C. K., Noh, S. H., Kim, J. J., Chung, H. C."Association of the ABCB1 3435C>T polymorphism and treatment outcomes in advanced gastric cancer patients treated with paclitaxel-based chemotherapy". Oncology Reports 23.1 (2010): 271-278.
Chicago
Chang, H., Rha, S. Y., Jeung, H., Im, C. K., Noh, S. H., Kim, J. J., Chung, H. C."Association of the ABCB1 3435C>T polymorphism and treatment outcomes in advanced gastric cancer patients treated with paclitaxel-based chemotherapy". Oncology Reports 23, no. 1 (2010): 271-278. https://doi.org/10.3892/or_00000633
Copy and paste a formatted citation
x
Spandidos Publications style
Chang H, Rha SY, Jeung H, Im CK, Noh SH, Kim JJ and Chung HC: Association of the ABCB1 3435C>T polymorphism and treatment outcomes in advanced gastric cancer patients treated with paclitaxel-based chemotherapy. Oncol Rep 23: 271-278, 2010.
APA
Chang, H., Rha, S.Y., Jeung, H., Im, C.K., Noh, S.H., Kim, J.J., & Chung, H.C. (2010). Association of the ABCB1 3435C>T polymorphism and treatment outcomes in advanced gastric cancer patients treated with paclitaxel-based chemotherapy. Oncology Reports, 23, 271-278. https://doi.org/10.3892/or_00000633
MLA
Chang, H., Rha, S. Y., Jeung, H., Im, C. K., Noh, S. H., Kim, J. J., Chung, H. C."Association of the ABCB1 3435C>T polymorphism and treatment outcomes in advanced gastric cancer patients treated with paclitaxel-based chemotherapy". Oncology Reports 23.1 (2010): 271-278.
Chicago
Chang, H., Rha, S. Y., Jeung, H., Im, C. K., Noh, S. H., Kim, J. J., Chung, H. C."Association of the ABCB1 3435C>T polymorphism and treatment outcomes in advanced gastric cancer patients treated with paclitaxel-based chemotherapy". Oncology Reports 23, no. 1 (2010): 271-278. https://doi.org/10.3892/or_00000633
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