miR-218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D

Cao,Quanxing; Dong,Pingshuan; Wang,Yanyu; Zhang,Junwei; Shi,Xinge; Wang,Yongsheng

doi:10.3892/or.2015.3861

miR-218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D

Authors:
- Quanxing Cao
- Pingshuan Dong
- Yanyu Wang
- Junwei Zhang
- Xinge Shi
- Yongsheng Wang
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Affiliations: Department of Cardiovascular Surgery, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China, Department of Cardiology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China
Published online on: March 18, 2015 https://doi.org/10.3892/or.2015.3861
Pages: 2606-2612

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Abstract

Cardiac myxoma is the most common type of human heart tumor, yet the molecular mechanism is still poorly understood. In the present study, we found that the level of myocyte enhancer factor 2D (MEF2D), a key regulatory protein for cardiac development, was elevated in specimens of cardiac myxoma, and was positively associated with the proliferation of myxoma cells. MEF2D suppression reduced the proliferation of myxoma cells and its tumorigenicity. Cell cycle progression was also inhibited by MEF2D suppression. miR-218, which is downregulated in myxoma, suppressed MEF2D expression by targeting its mRNA 3'UTR. Altogether, we found that miR-218/MEF2D may be an effective target for myxoma treatment.

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