Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis

  • Authors:
    • Malgorzata Szczepańska
    • Adrianna Mostowska
    • Przemyslaw Wirstlein
    • Jana Skrzypczak
    • Paweł P. Jagodziński
  • View Affiliations

  • Published online on: December 19, 2014     https://doi.org/10.3892/br.2014.409
  • Pages: 220-224
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Abstract

There are inconsistent data on the contribution of vascular endothelial growth factor (VEGF) ‑460 C/T (rs833061), +405 G/C (rs2010963) and +936 C/T (rs3025039) single‑nucleotide polymorphisms (SNPs) to endometriosis in different ethnicities. Therefore, using high‑resolution melting curve analysis, the present study examined the distribution of these SNPs in females with endometriosis‑related infertility and a control group. None of the three VEGF SNPs were associated with endometriosis‑related infertility in the dominant and recessive models. The lowest P‑values of the trend were observed for the VEGF +936 C/T (rs3025039) SNP in endometriosis‑related infertility (Ptrend=0.149). Similarly, haplotype analyses of VEGF SNPs did not demonstrate any SNP combination as a risk for endometriosis‑related infertility, and the lowest overall P‑values, P=0.141 and Pcorr=0.395, were observed for a haplotype (TGT) of the above SNPs. Taken together, these results did not demonstrate the contribution of VEGF C/T, +405 G/C and +936 C/T SNPs to endometriosis‑related infertility.
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March-2015
Volume 3 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Szczepańska M, Mostowska A, Wirstlein P, Skrzypczak J and Jagodziński PP: Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis. Biomed Rep 3: 220-224, 2015
APA
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., & Jagodziński, P.P. (2015). Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis. Biomedical Reports, 3, 220-224. https://doi.org/10.3892/br.2014.409
MLA
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Jagodziński, P. P."Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis". Biomedical Reports 3.2 (2015): 220-224.
Chicago
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Jagodziński, P. P."Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis". Biomedical Reports 3, no. 2 (2015): 220-224. https://doi.org/10.3892/br.2014.409