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In vivo protective effects of 6‑gingerol in cerebral ischemia involve preservation of antioxidant defenses and activation of anti‑apoptotic pathways

  • Authors:
    • Ratchaniporn Kongsui
    • Jinatta Jittiwat
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  • Published online on: April 4, 2024     https://doi.org/10.3892/br.2024.1773
  • Article Number: 85
  • Copyright: © Kongsui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Stroke is an important medical problem in developing countries, characterized by a sudden disruption of blood supply to the brain, either through occlusion or hemorrhage. It is a major cause of neurological impairment, resulting in high medical costs. The present study examined the effect of 6‑gingerol on morphological changes, antioxidant defenses, and the anti‑apoptotic factors p38 mitogen‑activated protein kinase (MAPK) and mitofusin (Mfn)2, in a rat model of focal cerebral ischemia. A total of 60 healthy male Wistar rats were randomly allocated into six groups: Control, right middle cerebral artery occlusion (Rt.MCAO) + vehicle, Rt.MCAO + piracetam, and Rt.MCAO + 6‑Gin 5, 10 and 20 mg/kg BW groups. The results indicated that 6‑gingerol treatment for a duration of 7 days reverses morphological alterations, enhances catalase and glutathione peroxidase activities, reduces Bax, caspase‑3 and MAPK expression, and increases Bcl‑xL and Mfn2 expression in the cortex and hippocampus. In conclusion, 6‑gingerol demonstrated significant in vivo effectiveness in mitigating pathological changes induced by cerebral ischemia. This beneficial effect is attributed, at least in part, to preservation of antioxidant defenses and activation of anti‑apoptotic pathways.
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June-2024
Volume 20 Issue 6

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Spandidos Publications style
Kongsui R and Kongsui R: <em>In vivo</em> protective effects of 6‑gingerol in cerebral ischemia involve preservation of antioxidant defenses and activation of anti‑apoptotic pathways. Biomed Rep 20: 85, 2024
APA
Kongsui, R., & Kongsui, R. (2024). <em>In vivo</em> protective effects of 6‑gingerol in cerebral ischemia involve preservation of antioxidant defenses and activation of anti‑apoptotic pathways. Biomedical Reports, 20, 85. https://doi.org/10.3892/br.2024.1773
MLA
Kongsui, R., Jittiwat, J."<em>In vivo</em> protective effects of 6‑gingerol in cerebral ischemia involve preservation of antioxidant defenses and activation of anti‑apoptotic pathways". Biomedical Reports 20.6 (2024): 85.
Chicago
Kongsui, R., Jittiwat, J."<em>In vivo</em> protective effects of 6‑gingerol in cerebral ischemia involve preservation of antioxidant defenses and activation of anti‑apoptotic pathways". Biomedical Reports 20, no. 6 (2024): 85. https://doi.org/10.3892/br.2024.1773