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Assessment of acute pancreatitis severity via determination of serum levels of hsa‑miR‑126‑5p and IL‑6

  • Authors:
    • Ying-Jie Chen
    • Tian-Lai Lin
    • Zhe Cai
    • Chang-Hu Yan
    • Sen-Ren Gou
    • Yao-Dong Zhuang

  • View Affiliations

  • Published online on: November 9, 2020     https://doi.org/10.3892/etm.2020.9458
  • Article Number: 26

  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Early assessment of acute pancreatitis (AP) severity is key to its treatment. The present study aimed to explore the role of microRNAs (miRNAs/miRs) combined with inflammatory factors in determining AP severity. For this, serum pro‑inflammatory cytokines [tumor necrosis factor (TNF)‑α, interleukin (IL)‑1, IL‑6, IL‑8 and IL‑10)] and miRNAs [Homo sapiens (hsa)‑miR‑548d‑5p, hsa‑miR‑126‑5p and hsa‑miR‑130b‑5p] were detected in patients with mild AP (MAP), severe AP (SAP) and recurrent AP (RAP). High expression of IL‑10, TNF‑α, hsa‑miR‑126‑5p, hsa‑miR‑548d‑5p and hsa‑miR‑130b‑5p was able to distinguish SAP from MAP and RAP (P<0.05). Multifactorial binary logistic regression analysis indicated that IL‑1/IL‑6 combined with hsa‑miR‑126‑5p/hsa‑miR‑548d‑5p had a significant influence on AP and AP severity (P<0.05). Receiver operating characteristic analysis revealed that IL‑1 combined with hsa‑miR‑126‑5p [area under the curve (AUC), 0.926; sensitivity, 90.0%; specificity, 86.7%, P<0.001] and IL‑6 combined with hsa‑miR‑126‑5p (AUC, 0.952; sensitivity, 93.3%; specificity, 90.0%; P<0.001) were able to better distinguish MAP from SAP than IL‑1/IL‑6 combined with hsa‑miR‑548d‑5p, lipase, and amylase. IL‑1 or IL‑6 combined with hsa‑miR‑548d‑5p (AUC, 0.924; sensitivity, 83.3%; specificity, 93.3%; P<0.001) were able to better distinguish SAP from RAP than IL‑1/IL‑6 combined with hsa‑miR‑126‑5p, lipase, and amylase. IL‑1 combined with hsa‑miR‑126‑5p (AUC, 0.926; sensitivity, 90.0%; specificity, 86.7%; P<0.001) and IL‑6 combined with hsa‑miR‑126‑5p (AUC, 0.952; sensitivity, 93.3%; specificity, 90.0%; P<0.001) were able to better differentiate between MAP and RAP than IL‑1/IL‑6 combined with hsa‑miR‑548d‑5p, lipase, and amylase. These results demonstrated that the combined detection of serum IL‑6 and hsa‑miR‑126‑5p may be useful for the early prediction of AP classification.
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Spandidos Publications style
Chen Y, Lin T, Cai Z, Yan C, Gou S and Zhuang Y: Assessment of acute pancreatitis severity via determination of serum levels of hsa‑miR‑126‑5p and IL‑6. Exp Ther Med 21: 26, 2021.
APA
Chen, Y., Lin, T., Cai, Z., Yan, C., Gou, S., & Zhuang, Y. (2021). Assessment of acute pancreatitis severity via determination of serum levels of hsa‑miR‑126‑5p and IL‑6. Experimental and Therapeutic Medicine, 21, 26. https://doi.org/10.3892/etm.2020.9458
MLA
Chen, Y., Lin, T., Cai, Z., Yan, C., Gou, S., Zhuang, Y."Assessment of acute pancreatitis severity via determination of serum levels of hsa‑miR‑126‑5p and IL‑6". Experimental and Therapeutic Medicine 21.1 (2021): 26.
Chicago
Chen, Y., Lin, T., Cai, Z., Yan, C., Gou, S., Zhuang, Y."Assessment of acute pancreatitis severity via determination of serum levels of hsa‑miR‑126‑5p and IL‑6". Experimental and Therapeutic Medicine 21, no. 1 (2021): 26. https://doi.org/10.3892/etm.2020.9458