Open Access

Lymphangiogenesis: A new strategy for heart disease treatment (Review)

  • Authors:
    • Liding Bai
    • Yanyan Wang
    • Siqi Du
    • Yumeng Si
    • Lu Chen
    • Lin Li
    • Yuhong Li
  • View Affiliations

  • Published online on: February 22, 2024     https://doi.org/10.3892/ijmm.2024.5359
  • Article Number: 35
  • Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Heart disease remains a global health challenge, contributing notably to morbidity and mortality. The lymphatic vasculature, an integral component of the cardiovascular system, plays a crucial role in regulating essential physiological processes, including fluid balance, transportation of extravasated proteins and immune cell trafficking, all of which are important for heart function. Through thorough scientometric analysis and extensive research, the present review identified lymphangiogenesis as a hotspot in cardiovascular disease research, and the mechanisms underlying impaired cardiac lymphangiogenesis and inadequate lymph drainage in various cardiovascular diseases are discussed. Furthermore, the way used to improve lymphangiogenesis to effectively regulate a variety of heart diseases and associated signaling pathways was investigated. Notably, the current review also highlights the impact of Traditional Chinese Medicine (TCM) on lymphangiogenesis, aiming to establish a clinical basis for the potential of TCM to improve cardiovascular diseases by promoting lymphangiogenesis.
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April-2024
Volume 53 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Bai L, Wang Y, Du S, Si Y, Chen L, Li L and Li Y: Lymphangiogenesis: A new strategy for heart disease treatment (Review). Int J Mol Med 53: 35, 2024
APA
Bai, L., Wang, Y., Du, S., Si, Y., Chen, L., Li, L., & Li, Y. (2024). Lymphangiogenesis: A new strategy for heart disease treatment (Review). International Journal of Molecular Medicine, 53, 35. https://doi.org/10.3892/ijmm.2024.5359
MLA
Bai, L., Wang, Y., Du, S., Si, Y., Chen, L., Li, L., Li, Y."Lymphangiogenesis: A new strategy for heart disease treatment (Review)". International Journal of Molecular Medicine 53.4 (2024): 35.
Chicago
Bai, L., Wang, Y., Du, S., Si, Y., Chen, L., Li, L., Li, Y."Lymphangiogenesis: A new strategy for heart disease treatment (Review)". International Journal of Molecular Medicine 53, no. 4 (2024): 35. https://doi.org/10.3892/ijmm.2024.5359