Open Access

Circular RNAs and the regulation of gene expression in diabetic nephropathy (Review)

  • Authors:
    • Maximo Berto Martinez Benitez
    • Yussel Pérez Navarro
    • Elisa Azuara‑Liceaga
    • Angeles Tecalco Cruz
    • Jesús Valdés Flores
    • Lilia Lopez‑Canovas
  • View Affiliations

  • Published online on: March 21, 2024     https://doi.org/10.3892/ijmm.2024.5368
  • Article Number: 44
  • Copyright: © Benitez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNAs (circRNAs) are non‑coding single‑stranded covalently closed RNA molecules that are considered important as regulators of gene expression at the transcriptional and post‑transcriptional levels. These molecules have been implicated in the initiation and progression of multiple human diseases, ranging from cancer to inflammatory and metabolic diseases, including diabetes mellitus and its vascular complications. The present article aimed to review the current knowledge on the biogenesis and functions of circRNAs, as well as their role in cell processes associated with diabetic nephropathy. In addition, novel potential interactions between circRNAs expressed in renal cells exposed to high‑glucose concentrations and the transcription factors c‑Jun and c‑Fos are reported.
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May-2024
Volume 53 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Benitez MM, Navarro YP, Azuara‑Liceaga E, Cruz AT, Flores JV and Lopez‑Canovas L: Circular RNAs and the regulation of gene expression in diabetic nephropathy (Review). Int J Mol Med 53: 44, 2024
APA
Benitez, M.M., Navarro, Y.P., Azuara‑Liceaga, E., Cruz, A.T., Flores, J.V., & Lopez‑Canovas, L. (2024). Circular RNAs and the regulation of gene expression in diabetic nephropathy (Review). International Journal of Molecular Medicine, 53, 44. https://doi.org/10.3892/ijmm.2024.5368
MLA
Benitez, M. M., Navarro, Y. P., Azuara‑Liceaga, E., Cruz, A. T., Flores, J. V., Lopez‑Canovas, L."Circular RNAs and the regulation of gene expression in diabetic nephropathy (Review)". International Journal of Molecular Medicine 53.5 (2024): 44.
Chicago
Benitez, M. M., Navarro, Y. P., Azuara‑Liceaga, E., Cruz, A. T., Flores, J. V., Lopez‑Canovas, L."Circular RNAs and the regulation of gene expression in diabetic nephropathy (Review)". International Journal of Molecular Medicine 53, no. 5 (2024): 44. https://doi.org/10.3892/ijmm.2024.5368