Open Access

Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review)

  • Authors:
    • Yajing Zhan
    • Ankang Yin
    • Xiyang Su
    • Nan Tang
    • Zebin Zhang
    • Yi Chen
    • Wei Wang
    • Juan Wang
  • View Affiliations

  • Published online on: April 2, 2024     https://doi.org/10.3892/ijmm.2024.5372
  • Article Number: 48
  • Copyright: © Zhan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Histone chaperones serve a pivotal role in maintaining human physiological processes. They interact with histones in a stable manner, ensuring the accurate and efficient execution of DNA replication, repair and transcription. Retinoblastoma binding protein (RBBP)4 and RBBP7 represent a crucial pair of histone chaperones, which not only govern the molecular behavior of histones H3 and H4, but also participate in the functions of several protein complexes, such as polycomb repressive complex 2 and nucleosome remodeling and deacetylase, thereby regulating the cell cycle, histone modifications, DNA damage and cell fate. A strong association has been indicated between RBBP4/7 and some major human diseases, such as cancer, age‑related memory loss and infectious diseases. The present review assesses the molecular mechanisms of RBBP4/7 in regulating cellular biological processes, and focuses on the variations in RBBP4/7 expression and their potential mechanisms in various human diseases, thus providing new insights for their diagnosis and treatment.
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May-2024
Volume 53 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zhan Y, Yin A, Su X, Tang N, Zhang Z, Chen Y, Wang W and Wang J: Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review). Int J Mol Med 53: 48, 2024
APA
Zhan, Y., Yin, A., Su, X., Tang, N., Zhang, Z., Chen, Y. ... Wang, J. (2024). Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review). International Journal of Molecular Medicine, 53, 48. https://doi.org/10.3892/ijmm.2024.5372
MLA
Zhan, Y., Yin, A., Su, X., Tang, N., Zhang, Z., Chen, Y., Wang, W., Wang, J."Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review)". International Journal of Molecular Medicine 53.5 (2024): 48.
Chicago
Zhan, Y., Yin, A., Su, X., Tang, N., Zhang, Z., Chen, Y., Wang, W., Wang, J."Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review)". International Journal of Molecular Medicine 53, no. 5 (2024): 48. https://doi.org/10.3892/ijmm.2024.5372