Open Access

Biological functions of circRNA in regulating the hallmarks of gastrointestinal cancer (Review)

  • Authors:
    • Mengjun Qiu
    • Youxiang Chen
    • Chunyan Zeng
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  • Published online on: March 15, 2024     https://doi.org/10.3892/ijo.2024.5637
  • Article Number: 49
  • Copyright: © Qiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNA (circRNA) was first observed in the cytoplasm of eukaryotic cells in 1979, but it was not characterized in detail until 2012, when high‑throughput sequencing technology was more advanced and available. Consequently, the mechanism of circRNA formation and its biological function have been progressively elucidated by researchers. circRNA is abundant in eukaryotic cells and exhibits a certain degree of organization, timing and disease‑specificity. Additionally, it is poorly degradable, meeting the characteristics of an ideal clinical biomarker. In the present review, the recent research progress of circRNAs in digestive tract malignant tumors was primarily discussed. This included the roles, biological functions and clinical significance of circRNA, providing references for its research value and clinical potential in gastrointestinal cancer.
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May-2024
Volume 64 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Qiu M, Chen Y and Zeng C: Biological functions of circRNA in regulating the hallmarks of gastrointestinal cancer (Review). Int J Oncol 64: 49, 2024
APA
Qiu, M., Chen, Y., & Zeng, C. (2024). Biological functions of circRNA in regulating the hallmarks of gastrointestinal cancer (Review). International Journal of Oncology, 64, 49. https://doi.org/10.3892/ijo.2024.5637
MLA
Qiu, M., Chen, Y., Zeng, C."Biological functions of circRNA in regulating the hallmarks of gastrointestinal cancer (Review)". International Journal of Oncology 64.5 (2024): 49.
Chicago
Qiu, M., Chen, Y., Zeng, C."Biological functions of circRNA in regulating the hallmarks of gastrointestinal cancer (Review)". International Journal of Oncology 64, no. 5 (2024): 49. https://doi.org/10.3892/ijo.2024.5637