Open Access

An overview of the regulatory role of annexin A1 in the tumor microenvironment and its prospective clinical application (Review)

  • Authors:
    • Kuan Gao
    • Xinyang Li
    • Shuya Luo
    • Limei Zhao
  • View Affiliations

  • Published online on: March 21, 2024     https://doi.org/10.3892/ijo.2024.5639
  • Article Number: 51
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Although annexin A1 (ANXA1), a 37 kDa phospholipid‑binding anti‑inflammatory protein expressed in various tissues and cell types, has been investigated extensively for its regulatory role in cancer biology, studies have mainly focused on its intracellular role. However, cancer cells and stromal cells expressing ANXA1 have the ability to transmit signals within the tumor microenvironment (TME) through autocrine, juxtacrine, or paracrine signaling. This bidirectional crosstalk between cancer cells and their environment is also crucial for cancer progression, contributing to uncontrolled tumor proliferation, invasion, metastasis and resistance to therapy. The present review explored the important role of ANXA1 in regulating the cell‑specific crosstalk between various compartments of the TME and analyzed the guiding significance of the crosstalk effects in promotion or suppressing cancer progression in the development of cancer treatments. The literature shows that ANXA1 is critical for the regulation of the TME, indicating that ANXA1 signaling between cancer cells and the TME is a potential therapeutic target for the development of novel therapeutic approaches for impeding cancer development.
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May-2024
Volume 64 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Gao K, Li X, Luo S and Zhao L: An overview of the regulatory role of annexin A1 in the tumor microenvironment and its prospective clinical application (Review). Int J Oncol 64: 51, 2024
APA
Gao, K., Li, X., Luo, S., & Zhao, L. (2024). An overview of the regulatory role of annexin A1 in the tumor microenvironment and its prospective clinical application (Review). International Journal of Oncology, 64, 51. https://doi.org/10.3892/ijo.2024.5639
MLA
Gao, K., Li, X., Luo, S., Zhao, L."An overview of the regulatory role of annexin A1 in the tumor microenvironment and its prospective clinical application (Review)". International Journal of Oncology 64.5 (2024): 51.
Chicago
Gao, K., Li, X., Luo, S., Zhao, L."An overview of the regulatory role of annexin A1 in the tumor microenvironment and its prospective clinical application (Review)". International Journal of Oncology 64, no. 5 (2024): 51. https://doi.org/10.3892/ijo.2024.5639