Prognostic value of serum α‑fetoprotein in ovarian yolk sac tumors: A systematic review and meta‑analysis

Guo,Yang‑Long; Zhang,Ying‑Li; Zhu,Jian‑Qing

doi:10.3892/mco.2014.417

Prognostic value of serum α‑fetoprotein in ovarian yolk sac tumors: A systematic review and meta‑analysis

Authors:
- Yang‑Long Guo
- Ying‑Li Zhang
- Jian‑Qing Zhu
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Affiliations: Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
Published online on: September 18, 2014 https://doi.org/10.3892/mco.2014.417
Pages: 125-132

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Abstract

This study was conducted to determine the prognostic value of serum α‑fetoprotein (AFP) levels in patients with ovarian yolk sac tumor (OYST). We performed a systematic review and meta‑analysis to assess the associations between serum AFP level and prognosis in OYST. A total of 12 quantitative studies met the inclusion criteria. Preoperative AFP was not found to be associated with overall survival (OS) [odds ratio (OR)=0.84, 95% confidence interval (CI): 0.43‑1.62] in OYST. However, a high postoperative AFP level was associated with worse OS (OR=0.16, 95% CI: 0.05‑0.48) and relapse‑free survival (RFS) (OR=0.18, 95% CI: 0.08‑0.43) compared to a low postoperative AFP level in patients with OYST. In addition, a postoperative AFP level of >1,000 ng̸ml was associated with a decrease in OS (OR=0.16, 95% CI: 0.05‑0.50) and RFS (OR=0.21, 95% CI: 0.08‑0.57). In conclusion, the postoperative, but not the preoperative, AFP level was found to be a prognostic factor in patients with OYST. In particular, a postoperative AFP level of >1,000 ng/ml was an indicator of poor prognosis in patients with OYST.

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