Association of the pri‑miR‑124‑1 rs531564 polymorphism with cancer risk: A meta‑analysis

Fang,Cheng; Zeng,Hui; Li,Anling; Xu,Xianqun; Long,Xinghua

doi:10.3892/mco.2015.547

Association of the pri‑miR‑124‑1 rs531564 polymorphism with cancer risk: A meta‑analysis

Authors:
- Cheng Fang
- Hui Zeng
- Anling Li
- Xianqun Xu
- Xinghua Long
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Affiliations: Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
Published online on: April 17, 2015 https://doi.org/10.3892/mco.2015.547
Pages: 892-896

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Abstract

Recently, several studies regarding the association between the pri‑miR‑124‑1 rs531564 polymorphism and cancer susceptibility were explored. Owing to inconsistent results of these studies, a meta‑analysis was conducted to determine the association of this polymorphism with cancer risk. Relevant studies were identified by a systematic search of PubMed, EMBASE, Web of Science and CNKI on‑line databases. Odds ratios (ORs) and 95% confidence intervals (CIs) from eligible studies were pooled, and heterogeneity and publication bias were also evaluated. A total of five studies with 2,253 cases and 2,510 controls were included in the meta‑analysis. Overall, the results showed that the pri‑miR‑124‑1 rs531564 polymorphism was significantly associated with a reduced cancer risk (G vs. C: OR, 0.86; 95% CI, 0.77‑0.96; GG vs. CC: OR, 0.52; 95% CI, 0.34‑0.79; GG vs. CG/CC: OR, 0.54; 95% CI, 0.36‑0.81). Furthermore, in the subgroup analysis by cancer sites, a statistical association was identified between the rs531564 polymorphism and a decreased esophageal squamous cell carcinoma (ESCC) risk (G vs. C: OR, 0.87; 95% CI, 0.77‑0.98; GG vs. CC: OR, 0.54; 95% CI, 0.34‑0.84). These findings suggested that the genetic variant of rs531564 may have a potential value in decreasing cancer risk, particularly in ESCC patients.

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1	Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI
2	Farh KK, Grimson A, Jan C, Lewis BP, Johnston WK, Lim LP, Burge CB and Bartel DP: The widespread impact of mammalian microRNAs on mRNA repression and evolution. Science. 310:1817–1821. 2005. View Article : Google Scholar : PubMed/NCBI
3	Ruan K, Fang X and Ouyang G: MicroRNAs: Novel regulators in the hallmarks of human cancer. Cancer Lett. 285:116–126. 2009. View Article : Google Scholar : PubMed/NCBI
4	Chen T, Li Z, Yan J, Yang X and Salminen W: MicroRNA expression profiles distinguish the carcinogenic effects of riddelliine in rat liver. Mutagenesis. 27:59–66. 2012. View Article : Google Scholar : PubMed/NCBI
5	Barbarotto E, Schmittgen TD and Calin GA: MicroRNAs and cancer: profile, profile, profile. Int J Cancer. 122:969–977. 2008. View Article : Google Scholar : PubMed/NCBI
6	Hu Z, Liang J, Wang Z, Tian T, Zhou X, Chen J, Miao R, Wang Y, Wang X and Shen H: Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women. Hum Mutat. 30:79–84. 2009. View Article : Google Scholar : PubMed/NCBI
7	Wang F, Sun G, Zou Y, Li Y, Hao L and Pan F: Association of microRNA-499 rs3746444 polymorphism with cancer risk: Evidence from 7188 cases and 8548 controls. PLoS One. 7:e450422012. View Article : Google Scholar : PubMed/NCBI
8	Roy R, De Sarkar N, Ghose S, Paul RR, Pal M, Bhattacharya C, Chowdhury SK, Ghosh S and Roy B: Genetic variations at microRNA and processing genes and risk of oral cancer. Tumour Biol. 35:3409–3414. 2014. View Article : Google Scholar : PubMed/NCBI
9	Qi L, Hu Y, Zhan Y, Wang J, Wang BB, Xia HF and Ma X: A SNP site in pri-miR-124 changes mature miR-124 expression but no contribution to Alzheimer's disease in a Mongolian population. Neurosci Lett. 515:1–6. 2012. View Article : Google Scholar : PubMed/NCBI
10	Yang H, Dinney CP, Ye Y, Zhu Y, Grossman HB and Wu X: Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. Cancer Res. 68:2530–2537. 2008. View Article : Google Scholar : PubMed/NCBI
11	Ye Y, Wang KK, Gu J, Yang H, Lin J, Ajani JA and Wu X: Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. Cancer Prev Res (Phila). 1:460–469. 2008. View Article : Google Scholar : PubMed/NCBI
12	Zhou Y, Du WD, Chen G, Ruan J, Xu S, Zhou FS, Zuo XB, Lv ZJ and Zhang XJ: Association analysis of genetic variants in microRNA networks and gastric cancer risk in a Chinese Han population. J Cancer Res Clin Oncol. 138:939–945. 2012. View Article : Google Scholar : PubMed/NCBI
13	Ma F, Zhang P, Lin D, Yu D, Yuan P, Wang J, Fan Y and Xu B: There is no association between microRNA gene polymorphisms and risk of triple negative breast cancer in a Chinese Han population. PLoS One. 8:e601952013. View Article : Google Scholar : PubMed/NCBI
14	Yin J, Wang X, Zheng L, et al: Hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population. PLoS One. 8:e805702013. View Article : Google Scholar : PubMed/NCBI
15	Xiong X, Cheng J, Liu X, Tang S and Luo X: Correlation analysis between miR-124 rs531564 polymorphisms and susceptibility to cervical cancer. Nan Fang Yi Ke Da Xue Xue Bao. 34:2102132014.(In Chinese). PubMed/NCBI
16	You WY: A Case Control study on the Association between Polymorphisms of microRNA Genes and Susceptibility for Kazakh's Esophageal Cancer (unpublished PhD thesis). Shihezi University 2011, (In Chinese).
17	Zhang J, Huang X, Xiao J, et al: Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations. PLoS One. 9:e1000552014. View Article : Google Scholar : PubMed/NCBI
18	Stang A: Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 25:603–605. 2010. View Article : Google Scholar : PubMed/NCBI
19	DerSimonian R and Kacker R: Random-effects model for meta-analysis of clinical trials: An update. Contemp Clin Trials. 28:105–114. 2007. View Article : Google Scholar : PubMed/NCBI
20	Xu W, Xu J, Liu S, Chen B, Wang X, Li Y, Qian Y, Zhao W and Wu J: Effects of common polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on cancer susceptibility: A meta-analysis. PLoS One. 6:e204712011. View Article : Google Scholar : PubMed/NCBI
21	Radojicic J, Zaravinos A, Vrekoussis T, Kafousi M, Spandidos DA and Stathopoulos EN: MicroRNA expression analysis in triple-negative (ER, PR and Her2/neu) breast cancer. Cell Cycle. 10:507–517. 2011. View Article : Google Scholar : PubMed/NCBI
22	Salzman DW and Weidhaas JB: SNPing cancer in the bud: microRNA and microRNA-target site polymorphisms as diagnostic and prognostic biomarkers in cancer. Pharmacol Ther. 137:55–63. 2013. View Article : Google Scholar : PubMed/NCBI
23	Nicoloso MS, Sun H, Spizzo R, et al: Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility. Cancer Res. 70:2789–2798. 2010. View Article : Google Scholar : PubMed/NCBI
24	Jin Y and Lee CG: Single Nucleotide Polymorphisms Associated with microRNA Regulation. Biomolecules. 3:287–302. 2013. View Article : Google Scholar : PubMed/NCBI
25	Shi XB, Xue L, Ma AH, Tepper CG, Gandour-Edwards R, Kung HJ and deVere White RW: Tumor suppressive miR-124 targets androgen receptor and inhibits proliferation of prostate cancer cells. Oncogene. 32:4130–4138. 2013. View Article : Google Scholar : PubMed/NCBI
26	Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I and Inazawa J: miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis. 31:766–776. 2010. View Article : Google Scholar : PubMed/NCBI
27	Silber J, Lim DA, Petritsch C, et al: miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 6:142008. View Article : Google Scholar : PubMed/NCBI