Incidence of renal carcinoma in non-functioning kidney due to renal pelvic stone disease

Zengin,Kursad; Tanik,Serhat; Sener,Nevzat   Can; Albayrak,Sebahattin; Ekici,Musa; Bozkurt,Ibrahim  Halil; Bakirtas,Hasan; Gurdal,Mesut; Imamoglu,Muhammed  Abdurrahim

doi:10.3892/mco.2015.550

Incidence of renal carcinoma in non-functioning kidney due to renal pelvic stone disease

Authors:
- Kursad Zengin
- Serhat Tanik
- Nevzat Can Sener
- Sebahattin Albayrak
- Musa Ekici
- Ibrahim Halil Bozkurt
- Hasan Bakirtas
- Mesut Gurdal
- Muhammed Abdurrahim Imamoglu
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Affiliations: Department of Urology, Faculty of Medicine, Bozok University, 66200 Yozgat, Turkey, Department of Urology, Numune Education and Research Hospital, 01010 Adana, Turkey, Department of Urology, Faculty of Medicine, Hitit University, 19100 Corum, Turkey, Department of Urology, Bozyaka Education and Research Hospital, 35140 Izmir, Turkey
Published online on: April 24, 2015 https://doi.org/10.3892/mco.2015.550
Pages: 941-943

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Abstract

The objective of this study was to report our pathological findings in nephrectomy specimens from patients treated for non‑functioning hydronephrotic kidney due to renal pelvic stone disease. A total of 97 patients who underwent nephrectomy for non‑functioning hydronephrotic kidneys between January, 2011 and June, 2014 were retrospectively reviewed. A non‑functioning kidney was defined as one having paper‑thin parenchyma on urinary ultrasound or computed tomography, exhibiting no contrast visualization in the collecting duct system on intravenous urography and having a split renal function of <10% on nuclear renal function studies. Following pathological evaluation, 9 patients were diagnosed with xanthogranulomatous pyelonephritis, 9 with malignant tumors and 79 with chronic pyelonephritis. Of the patients with chronic pyelonephritis, 2 also had renal adenomas. The malignant tumors included 3 transitional cell carcinomas (TCC), 2 squamous cell carcinomas (SCC), 3 renal cell carcinomas (RCC) (1 sarcomatoid, 1 papillary and 1 clear cell RCC), whereas 1 patient had concurrent RCC and TCC. In conclusion, non‑functioning kidneys, particularly those with kidney stones, should be managed as possible malignancies, due to the higher incidence of malignant tumors in such patients compared with the normal population.

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