Open Access

Optimizing perampanel monotherapy for surgically resected brain tumors

  • Authors:
    • Utaro Hino
    • Ryota Tamura
    • Kenzo Kosugi
    • Taketo Ezaki
    • Kosuke Karatsu
    • Kosei Yamamoto
    • Azuna Tomioka
    • Masahiro Toda
  • View Affiliations

  • Published online on: April 30, 2024     https://doi.org/10.3892/mco.2024.2740
  • Article Number: 42
  • Copyright: © Hino et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Perampanel (PER) is an antiseizure medication (ASM) with a unique mechanism of action, which was approved in Japan for use in combination therapy in 2016 and as a monotherapy in 2020. It has exerted antitumor effects against several types of tumors in vitro. However, the efficacy of PER monotherapy for seizure control is not well‑established in patients with brain tumor. In the present study, 25 patients with brain tumor treated using PER monotherapy at our institution were analyzed and compared with 45 patients treated using the most commonly prescribed ASM, levetiracetam (LEV). The PER group was younger and had a higher frequency of glioma cases. During drug administration, seizures were observed in two patients from the PER group (8.0%) and five patients from the LEV group (11.1%); however, the difference was not significant. The incidence of adverse effects did not significantly differ between the groups (12.0 and 2.2%, respectively). In the PER group, mild liver dysfunction was observed in two patients and drug rash in one. In the LEV group, a drug‑induced rash was observed in one patient. PER monotherapy may be safe and effective for seizure treatment or prophylaxis in patients with brain tumor. Further large‑scale clinical studies are warranted.
View Figures
View References

Related Articles

Journal Cover

June-2024
Volume 20 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hino U, Tamura R, Kosugi K, Ezaki T, Karatsu K, Yamamoto K, Tomioka A and Toda M: Optimizing perampanel monotherapy for surgically resected brain tumors. Mol Clin Oncol 20: 42, 2024
APA
Hino, U., Tamura, R., Kosugi, K., Ezaki, T., Karatsu, K., Yamamoto, K. ... Toda, M. (2024). Optimizing perampanel monotherapy for surgically resected brain tumors. Molecular and Clinical Oncology, 20, 42. https://doi.org/10.3892/mco.2024.2740
MLA
Hino, U., Tamura, R., Kosugi, K., Ezaki, T., Karatsu, K., Yamamoto, K., Tomioka, A., Toda, M."Optimizing perampanel monotherapy for surgically resected brain tumors". Molecular and Clinical Oncology 20.6 (2024): 42.
Chicago
Hino, U., Tamura, R., Kosugi, K., Ezaki, T., Karatsu, K., Yamamoto, K., Tomioka, A., Toda, M."Optimizing perampanel monotherapy for surgically resected brain tumors". Molecular and Clinical Oncology 20, no. 6 (2024): 42. https://doi.org/10.3892/mco.2024.2740