Open Access

Dicer affects cisplatin‑mediated apoptosis in epithelial ovarian cancer cells

  • Authors:
    • Xi Wang
    • Hui Chen
    • Yiping Wen
    • Xiaoxin Yang
    • Qing Han
    • Ping Jiang
    • Zaiju Huang
    • Jing Cai
    • Zehua Wang
  • View Affiliations

  • Published online on: September 4, 2018     https://doi.org/10.3892/mmr.2018.9452
  • Pages: 4381-4387
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Dicer is an essential enzyme that processes micro (mi)-RNA precursors into mature miRNAs, and serves a critical role in cancer development and progression by regulating gene expression. However, the role of Dicer in cisplatin‑mediated apoptosis and chemotherapy resistance in epithelial ovarian cancer (EOC) cells is poorly understood. In the present study, Dicer was expressed at low levels in cisplatin‑resistant A2780 cells when compared with parental cells. In addition, knocking down Dicer using short hairpin RNA decreased the sensitivity of A2780 and CAOV3 cells to cisplatin. Furthermore, downregulating Dicer significantly inhibited cisplatin‑induced apoptosis in ovarian cancer cells, and decreased the levels of proteins involved in apoptosis signaling pathways, including P73, P63, P53, caspase‑9 and caspase‑3. These findings indicated that Dicer may be a promising target for overcoming drug resistance in ovarian cancer.
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November-2018
Volume 18 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Wang X, Chen H, Wen Y, Yang X, Han Q, Jiang P, Huang Z, Cai J and Wang Z: Dicer affects cisplatin‑mediated apoptosis in epithelial ovarian cancer cells. Mol Med Rep 18: 4381-4387, 2018.
APA
Wang, X., Chen, H., Wen, Y., Yang, X., Han, Q., Jiang, P. ... Wang, Z. (2018). Dicer affects cisplatin‑mediated apoptosis in epithelial ovarian cancer cells. Molecular Medicine Reports, 18, 4381-4387. https://doi.org/10.3892/mmr.2018.9452
MLA
Wang, X., Chen, H., Wen, Y., Yang, X., Han, Q., Jiang, P., Huang, Z., Cai, J., Wang, Z."Dicer affects cisplatin‑mediated apoptosis in epithelial ovarian cancer cells". Molecular Medicine Reports 18.5 (2018): 4381-4387.
Chicago
Wang, X., Chen, H., Wen, Y., Yang, X., Han, Q., Jiang, P., Huang, Z., Cai, J., Wang, Z."Dicer affects cisplatin‑mediated apoptosis in epithelial ovarian cancer cells". Molecular Medicine Reports 18, no. 5 (2018): 4381-4387. https://doi.org/10.3892/mmr.2018.9452