Clinicopathological analysis of CD44 and CD24 expression in invasive breast cancer

  • Authors:
    • Min Hye Jang
    • Hyun Jong Kang
    • Ki Seok Jang
    • Seung Sam Paik
    • Wan Seop Kim
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  • Published online on: August 10, 2016     https://doi.org/10.3892/ol.2016.4987
  • Pages: 2728-2733
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Abstract

A subpopulation of breast cancer cells with cluster of differentiation (CD)44-positive and CD24‑negative expression has been reported to have stem cell properties and to have a higher tumorigenic capacity than other cells. However, the clinico­pathological characteristics of this subpopulation are not fully understood. In this study, we aimed to identify the correlations between the expression of CD44 and CD24 and clinicopathological parameters and overall survival. We studied specimens from 262 patients with invasive breast cancer. Immunohistochemical staining for CD44 and CD24 was performed using tissue microarrays. The clinico­pathological factors were evaluated from the patients' medical records. In correlation analysis, CD44 expression was significantly associated with human epidermal growth factor receptor 2 (HER2)‑negative status (P<0.001). Conversely, CD24 expression was significantly associated with HER2‑positive status (P<0.001). CD44 and CD24 expression did not demonstrate any correlation with the age, tumor size, axillary lymph node metastasis status, tumor stage, histological grade, estrogen receptor status and progesterone receptor status of patients. Upon survival analysis, there was no statistical difference in overall survival according to the expression of CD44 and CD24. The results from this study suggest that CD44 and CD24 are clinically significant markers associated with breast tumorigenesis, but not sufficient factors in determining the prognosis of invasive breast cancer.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jang MH, Kang HJ, Jang KS, Paik SS and Kim WS: Clinicopathological analysis of CD44 and CD24 expression in invasive breast cancer. Oncol Lett 12: 2728-2733, 2016.
APA
Jang, M.H., Kang, H.J., Jang, K.S., Paik, S.S., & Kim, W.S. (2016). Clinicopathological analysis of CD44 and CD24 expression in invasive breast cancer. Oncology Letters, 12, 2728-2733. https://doi.org/10.3892/ol.2016.4987
MLA
Jang, M. H., Kang, H. J., Jang, K. S., Paik, S. S., Kim, W. S."Clinicopathological analysis of CD44 and CD24 expression in invasive breast cancer". Oncology Letters 12.4 (2016): 2728-2733.
Chicago
Jang, M. H., Kang, H. J., Jang, K. S., Paik, S. S., Kim, W. S."Clinicopathological analysis of CD44 and CD24 expression in invasive breast cancer". Oncology Letters 12, no. 4 (2016): 2728-2733. https://doi.org/10.3892/ol.2016.4987