Management of brain metastasis from rectal cancer using whole‑brain radiation therapy followed by bevacizumab and chemotherapy: A case report

  • Authors:
    • Hung Van Nguyen
    • Duong Thuy Phung
    • Trung Thanh Nguyen
    • Bach Trung Tran
    • Kim Ngan Thi Mai
    • Huy Le Trinh
  • View Affiliations

  • Published online on: August 30, 2023     https://doi.org/10.3892/ol.2023.14033
  • Article Number: 446
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Abstract

Brain metastases in colorectal cancer are uncommon, which has resulted in a shortage of data concerning their screening and management. Multiple therapeutic modalities with chemotherapy, chemoradiation and targeted therapy, including bevacizumab and cetuximab regimens, have shown promising results. The present study describes the case of a 47‑year‑old male, diagnosed with T4N2M1 rectal cancer who underwent systemic therapy with modified FOLFOXIRI and cetuximab. The patient achieved a complete clinical response after 12 cycles. Following the discontinuation of cetuximab, the patient was given capecitabine as a maintenance therapy and subsequently developed brain metastasis. The patient received whole‑brain radiation therapy (WBRT) followed by a bevacizumab plus FOLFIRI regimen. The patient showed a good response as revealed by cranial magnetic resonance imaging, with a reduction in lesion size and no sign of cerebral edema. In addition, the patient maintained a stable neurological condition for >10 months. These findings suggest that the early detection of brain metastases requires the close monitoring of neurological symptoms. In addition, WBRT followed by bevacizumab and chemotherapy is a potential management plan for brain metastasis from rectal cancer.
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October-2023
Volume 26 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Nguyen HV, Phung DT, Nguyen TT, Tran BT, Thi Mai KN and Trinh HL: Management of brain metastasis from rectal cancer using whole‑brain radiation therapy followed by bevacizumab and chemotherapy: A case report. Oncol Lett 26: 446, 2023
APA
Nguyen, H.V., Phung, D.T., Nguyen, T.T., Tran, B.T., Thi Mai, K.N., & Trinh, H.L. (2023). Management of brain metastasis from rectal cancer using whole‑brain radiation therapy followed by bevacizumab and chemotherapy: A case report. Oncology Letters, 26, 446. https://doi.org/10.3892/ol.2023.14033
MLA
Nguyen, H. V., Phung, D. T., Nguyen, T. T., Tran, B. T., Thi Mai, K. N., Trinh, H. L."Management of brain metastasis from rectal cancer using whole‑brain radiation therapy followed by bevacizumab and chemotherapy: A case report". Oncology Letters 26.4 (2023): 446.
Chicago
Nguyen, H. V., Phung, D. T., Nguyen, T. T., Tran, B. T., Thi Mai, K. N., Trinh, H. L."Management of brain metastasis from rectal cancer using whole‑brain radiation therapy followed by bevacizumab and chemotherapy: A case report". Oncology Letters 26, no. 4 (2023): 446. https://doi.org/10.3892/ol.2023.14033