Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment

  • Authors:
    • Hua Ye
    • Wenwen Yu
    • Yangyang Ni
    • Xiaoqiong Bao
    • Xie Zhang
    • Yunlei Li
    • Ali Chen
    • Jifa Li
    • Long Zheng
  • View Affiliations

  • Published online on: March 5, 2024     https://doi.org/10.3892/ol.2024.14327
  • Article Number: 194
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Abstract

Apatinib plus chemotherapy demonstrates good efficacy in multiple advanced carcinomas; however, its use in patients with advanced lung adenocarcinoma (LUAD) has not yet been assessed. The present study evaluated the potential benefits of apatinib plus chemotherapy in patients with advanced LUAD. A total of 145 patients with advanced LUAD and negative driver genes who received apatinib plus chemotherapy (n=65) or chemotherapy alone (n=80) were analyzed. The overall response rate was significantly improved by apatinib plus chemotherapy vs. chemotherapy alone (53.8 vs. 36.3%; P=0.034). Moreover, progression‑free survival (PFS) was significantly longer in patients who received apatinib plus chemotherapy, compared with those who received chemotherapy alone [median (95% CI), 13.4 months (11.5‑15.3) vs. 8.2 months (6.9‑9.5); P<0.001], as was overall survival (OS) [median (95% CI), 23.1 months (not reached) vs. 17.0 months (14.6‑19.4; P=0.001). Following adjustment by multivariate Cox regression analysis, apatinib plus chemotherapy was associated with a significantly longer PFS [hazard ratio (HR), 0.444; P<0.001] and OS (HR, 0.347; P<0.001), compared with chemotherapy alone. Subgroup analyses revealed that PFS and OS were significantly improved following apatinib plus chemotherapy vs. chemotherapy alone (all P<0.05) in patients receiving first‑ or second‑line treatment. Notably, the incidence of hypertension was significantly increased following apatinib plus chemotherapy vs. chemotherapy alone (43.1 vs. 25.0%; P=0.021), whereas the incidence of other adverse events was not significantly different between the two treatment groups (all P>0.05). In conclusion, apatinib plus chemotherapy is associated with an improved treatment response and survival compared with chemotherapy alone, with a tolerable safety profile in patients with advanced LUAD.
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May-2024
Volume 27 Issue 5

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Spandidos Publications style
Ye H, Yu W, Ni Y, Bao X, Zhang X, Li Y, Chen A, Li J and Zheng L: Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment. Oncol Lett 27: 194, 2024
APA
Ye, H., Yu, W., Ni, Y., Bao, X., Zhang, X., Li, Y. ... Zheng, L. (2024). Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment. Oncology Letters, 27, 194. https://doi.org/10.3892/ol.2024.14327
MLA
Ye, H., Yu, W., Ni, Y., Bao, X., Zhang, X., Li, Y., Chen, A., Li, J., Zheng, L."Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment". Oncology Letters 27.5 (2024): 194.
Chicago
Ye, H., Yu, W., Ni, Y., Bao, X., Zhang, X., Li, Y., Chen, A., Li, J., Zheng, L."Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment". Oncology Letters 27, no. 5 (2024): 194. https://doi.org/10.3892/ol.2024.14327