Open Access

p160 nuclear receptor coactivator family members and their role in rare fusion‑driven neoplasms (Review)

  • Authors:
    • Danilo Segovia
    • Polona Safaric Tepes
  • View Affiliations

  • Published online on: March 14, 2024     https://doi.org/10.3892/ol.2024.14343
  • Article Number: 210
  • Copyright: © Segovia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gene fusions with translocations involving nuclear receptor coactivators (NCoAs) are relatively common among fusion‑driven malignancies. NCoAs are essential mediators of environmental cues and can modulate the transcription of downstream target genes upon binding to activated nuclear receptors. Therefore, fusion proteins containing NCoAs can become strong oncogenic drivers, affecting the cell transcriptional profile. These tumors show a strong dependency on the fusion oncogene; therefore, the direct pharmacological targeting of the fusion protein becomes an attractive strategy for therapy. Currently, different combinations of chemotherapy regimens are used to treat a variety of NCoA‑fusion‑driven tumors, but given the frequent tumor reoccurrence, more efficient treatment strategies are needed. Specific approaches directed towards inhibition or silencing of the fusion gene need to be developed while minimizing the interference with the original genes. This review highlights the relevant literature describing the normal function and structure of NCoAs and their oncogenic activity in NCoA‑gene fusion‑driven cancers, and explores potential strategies that could be effective in targeting these fusions. 
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May-2024
Volume 27 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Segovia D and Segovia D: p160 nuclear receptor coactivator family members and their role in rare fusion‑driven neoplasms (Review). Oncol Lett 27: 210, 2024
APA
Segovia, D., & Segovia, D. (2024). p160 nuclear receptor coactivator family members and their role in rare fusion‑driven neoplasms (Review). Oncology Letters, 27, 210. https://doi.org/10.3892/ol.2024.14343
MLA
Segovia, D., Tepes, P. S."p160 nuclear receptor coactivator family members and their role in rare fusion‑driven neoplasms (Review)". Oncology Letters 27.5 (2024): 210.
Chicago
Segovia, D., Tepes, P. S."p160 nuclear receptor coactivator family members and their role in rare fusion‑driven neoplasms (Review)". Oncology Letters 27, no. 5 (2024): 210. https://doi.org/10.3892/ol.2024.14343