Pathogenesis and treatment advances of degenerative diseases in spine and joints.

The spine and joints constitute important structures for human activity. With aging, as well as many factors such as obesity, labor injury, and trauma, the spine and joints undergo degenerative changes, causing symptoms such as pain and restricted movement, seriously affecting the quality of life and becoming a huge social and medical resource consumption source. For disabling diseases caused by degeneration of the spine and joints, such as lumbar disc herniation, lumbar spondylolisthesis, knee osteoarthritis, etc., the currently available treatment options are limited, and drug and highly invasive surgical treatments only address acute symptoms, lacking reliable measures to prevent or reverse the degenerative process. Due to insufficient understanding of the disease, limitations of drug and surgical treatments, and other factors, degeneration in the spine and joints remains a challenging aspect of degenerative diseases. This special issue invites researchers to focus on the latest advances in the pathogenesis and treatment of degeneration in the spine and joints, in order to address the challenges currently being faced. The following topics are welcome but not limited to: 1.Advances, basic research and clinical research related to spine and joint degeneration.； 2.Pathogenesis and treatment advances of degenerative spinal diseases, including intervertebral disc degeneration, spondylolisthesisp, degenerative scoliosis, vertebral osteoporotic fracture, etc.； 3.Pathogenesis and treatment advances of degenerative joint diseases, including osteoporosis, osteoarthritis, femoral head necrosis, ligament damage, etc.