Open Access

Potential of olfactory neuroepithelial cells as a model to study schizophrenia: A focus on GPCRs (Review)

  • Authors:
    • Zuly A. Sánchez‑Florentino
    • Bianca S. Romero‑Martínez
    • Edgar Flores‑Soto
    • Héctor Serrano
    • Luis M. Montaño
    • Marcela Valdés‑Tovar
    • Eduardo Calixto
    • Arnoldo Aquino‑Gálvez
    • Germán O. López‑Riquelme
    • Ramón Alvarado
    • Jesús Argueta
    • Héctor Solís‑Chagoyán
    • Bettina Sommer
  • View Affiliations

  • Published online on: November 28, 2023     https://doi.org/10.3892/ijmm.2023.5331
  • Article Number: 7
  • Copyright: © Sánchez‑Florentino et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Schizophrenia (SZ) is a multifactorial disorder characterized by volume reduction in gray and white matter, oxidative stress, neuroinflammation, altered neurotransmission, as well as molecular deficiencies such as punctual mutation in Disrupted‑in‑Schizophrenia 1 protein. In this regard, it is essential to understand the underlying molecular disturbances to determine the pathophysiological mechanisms of the disease. The signaling pathways activated by G protein‑coupled receptors (GPCRs) are key molecular signaling pathways altered in SZ. Convenient models need to be designed and validated to study these processes and mechanisms at the cellular level. Cultured olfactory stem cells are used to investigate neural molecular and cellular alterations related to the pathophysiology of SZ. Multipotent human olfactory stem cells are undifferentiated and express GPCRs involved in numerous physiological functions such as proliferation, differentiation and bioenergetics. The use of olfactory stem cells obtained from patients with SZ may identify alterations in GPCR signaling that underlie dysfunctional processes in both undifferentiated and specialized neurons or derived neuroglia. The present review aimed to analyze the role of GPCRs and their signaling in the pathophysiology of SZ. Culture of olfactory epithelial cells constitutes a suitable model to study SZ and other psychiatric disorders at the cellular level.
View Figures
View References

Related Articles

Journal Cover

January-2024
Volume 53 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Sánchez‑Florentino ZA, Romero‑Martínez BS, Flores‑Soto E, Serrano H, Montaño LM, Valdés‑Tovar M, Calixto E, Aquino‑Gálvez A, López‑Riquelme GO, Alvarado R, Alvarado R, et al: Potential of olfactory neuroepithelial cells as a model to study schizophrenia: A focus on GPCRs (Review). Int J Mol Med 53: 7, 2024
APA
Sánchez‑Florentino, Z.A., Romero‑Martínez, B.S., Flores‑Soto, E., Serrano, H., Montaño, L.M., Valdés‑Tovar, M. ... Sommer, B. (2024). Potential of olfactory neuroepithelial cells as a model to study schizophrenia: A focus on GPCRs (Review). International Journal of Molecular Medicine, 53, 7. https://doi.org/10.3892/ijmm.2023.5331
MLA
Sánchez‑Florentino, Z. A., Romero‑Martínez, B. S., Flores‑Soto, E., Serrano, H., Montaño, L. M., Valdés‑Tovar, M., Calixto, E., Aquino‑Gálvez, A., López‑Riquelme, G. O., Alvarado, R., Argueta, J., Solís‑Chagoyán, H., Sommer, B."Potential of olfactory neuroepithelial cells as a model to study schizophrenia: A focus on GPCRs (Review)". International Journal of Molecular Medicine 53.1 (2024): 7.
Chicago
Sánchez‑Florentino, Z. A., Romero‑Martínez, B. S., Flores‑Soto, E., Serrano, H., Montaño, L. M., Valdés‑Tovar, M., Calixto, E., Aquino‑Gálvez, A., López‑Riquelme, G. O., Alvarado, R., Argueta, J., Solís‑Chagoyán, H., Sommer, B."Potential of olfactory neuroepithelial cells as a model to study schizophrenia: A focus on GPCRs (Review)". International Journal of Molecular Medicine 53, no. 1 (2024): 7. https://doi.org/10.3892/ijmm.2023.5331