Diagnostic accuracy of diffusion-weighted whole-body imaging with background body signal suppression/T2-weighted image fusion for the detection of abdominal solid cancer

Tomizawa,Minoru; Shinozaki,Fuminobu; Fugo,Kazunori; Tanaka,Satomi; Sunaoshi,Takafumi; Kano,Daisuke; Sugiyama,Eriko; Shite,Misaki; Haga,Ryouta; Fukamizu,Yoshiya; Fujita,Toshiyuki; Kagayama,Satoshi; Hasegawa,Rumiko; Togawa,Akira; Shirai,Yoshinori; Ichiki,Noboru; Oshima,Yuji; Koike,Naoto; Toshimitsu,Yasuko; Motoyoshi,Yasufumi; Sugiyama,Takao; Yamamoto,Shigenori; Kishimoto,Takashi; Ishige,Naoki

doi:10.3892/etm.2017.4432

Diagnostic accuracy of diffusion-weighted whole-body imaging with background body signal suppression/T2-weighted image fusion for the detection of abdominal solid cancer

Authors:
- Minoru Tomizawa
- Fuminobu Shinozaki
- Kazunori Fugo
- Satomi Tanaka
- Takafumi Sunaoshi
- Daisuke Kano
- Eriko Sugiyama
- Misaki Shite
- Ryouta Haga
- Yoshiya Fukamizu
- Toshiyuki Fujita
- Satoshi Kagayama
- Rumiko Hasegawa
- Akira Togawa
- Yoshinori Shirai
- Noboru Ichiki
- Yuji Oshima
- Naoto Koike
- Yasuko Toshimitsu
- Yasufumi Motoyoshi
- Takao Sugiyama
- Shigenori Yamamoto
- Takashi Kishimoto
- Naoki Ishige
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Affiliations: Department of Gastroenterology, National Hospital Organization, Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Radiology, National Hospital Organization, Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba, Chiba 260‑8670, Japan, Department of Surgery, National Hospital Organization, Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Surgery, Seirei Sakura Citizen Hospital, Sakura, Chiba 285‑8765, Japan, Department of Surgery, National Hospital Organization Chiba Medical Center, Chiba, Chiba 260‑8606, Japan, Department of Neurology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Rheumatology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Pediatrics, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Neurosurgery, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan
Published online on: May 5, 2017 https://doi.org/10.3892/etm.2017.4432
Pages: 3509-3515

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Abstract

Diffusion-weighted whole‑body imaging with background body signal suppression (DWIBS) images show significant contrast for cancer tissues against non‑cancerous tissues. Fusion of a DWIBS and a T2‑weighted image (DWIBS/T2) can be used to obtain functional, as well as anatomic, information. In the present study, the performance of DWIBS/T2 in the diagnosis of abdominal solid cancer was evaluated. The records of 14 patients were retrospectively analyzed [5 patients with hepatocellular carcinoma (HCC), 4 with metastatic liver cancer, 3 with pancreatic cancer, 1 with renal cellular carcinoma and 1 with malignant lymphoma of the para‑aortic lymph node]. T1WI and T2WI scans did not detect pancreatic cancer in certain cases, whereas DWIs and DWIBS/T2 clearly demonstrated pancreatic cancer in all cases. In addition, metastatic liver cancer and HCC were successfully detected with abdominal US and CECT; however, US did not detect pancreatic cancer in 1 case, while CECT and DWIBS/T2 detected pancreatic cancer in all cases. In conclusion, the diagnostic performance of DWIBS/T2 was the same as that of abdominal US and CECT in detecting primary and metastatic liver cancer. DWIBS/T2 enabled the diagnosis of pancreatic cancer in cases where it was not detected with US, T1WI or T2WI.