Journal Articles

Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiforme (Review)

Gang Wang, Jun-Jie Wang, Xing-Li Fu, Rui Guang, Shing-Shun Tony To

Pages: 657-670 Published online on: 09 December 2016

Immature myeloid-derived suppressor cells: A bridge between inflammation and cancer (Review)

Caterina Musolino, Alessandro Allegra, Govanni Pioggia, Sebastiano Gangemi

Pages: 671-683 Published online on: 05 December 2016
Open Access

Spirulina lipopolysaccharides inhibit tumor growth in a Toll-like receptor 4-dependent manner by altering the cytokine milieu from interleukin-17/interleukin-23 to interferon-γ

Hiromi Okuyama, Akira Tominaga, Satoshi Fukuoka, Takahiro Taguchi, Yutaka Kusumoto, Shiro Ono

Pages: 684-694 Published online on: 02 January 2017
Open Access

Chemoradiotherapy and concurrent radiofrequency thermal therapy to treat primary rectal cancer and prediction of treatment responses

Hisanori Shoji, Masahiko Motegi, Yosuke Takakusagi, Takayuki Asao, Hiroyuki Kuwano, Takeo Takahashi, Kyoji Ogoshi

Pages: 695-704 Published online on: 07 December 2016
Open Access

Fulvestrant reverses doxorubicin resistance in multidrug-resistant breast cell lines independent of estrogen receptor expression

Yuan Huang, Donghai Jiang, Meihua Sui, Xiaojia Wang, Weimin Fan

Pages: 705-712 Published online on: 14 December 2016
Open Access

Transforming growth factor-β1 suppresses bone morphogenetic protein-2-induced mesenchymal-epithelial transition in HSC-4 human oral squamous cell carcinoma cells via Smad1/5/9 pathway suppression

Takahiro Chiba, Akira Ishisaki, Seiko Kyakumoto, Toshiyuki Shibata, Hiroyuki Yamada, Masaharu Kamo

Pages: 713-720 Published online on: 28 December 2016
Open Access

Monoclonal antibody Zt/g4 targeting RON receptor tyrosine kinase enhances chemosensitivity of bladder cancer cells to Epirubicin by promoting G1/S arrest and apoptosis

Jun-Feng Chen, Bi-Xia Yu, Rui Yu, Liang Ma, Xiu-Yi Lv, Yue Cheng, Qi Ma

Pages: 721-728 Published online on: 05 January 2017
Open Access

Berberine affects osteosarcoma via downregulating the caspase-1/IL-1β signaling axis

Hao Jin, Xin Jin, Boran Cao, Wenbo Wang

Pages: 729-736 Published online on: 16 December 2016
Open Access

NF‑κB inhibition is associated with OPN/MMP‑9 downregulation in cutaneous melanoma

Claudio Guarneri, Valentina Bevelacqua, Jerry Polesel, Luca Falzone, Patrizia S. Cannavò, Demetrios A. Spandidos, Grazia Malaponte, Massimo Libra

Pages: 737-746 Published online on: 10 January 2017
Open Access

Oxymatrine inhibits the migration of human colorectal carcinoma RKO cells via inhibition of PAI-1 and the TGF-β1/Smad signaling pathway

Xiaoyu Wang, Chun Liu, Jiaqi Wang, Yue Fan, Zhenghua Wang, Yuanyuan Wang

Pages: 747-753 Published online on: 07 December 2016
Open Access

Synergisic effect of APRIL knockdown and Jiedu Xiaozheng Yin, a Chinese medicinal recipe, on the inhibition of hepatocellular carcinoma cell proliferation

Zhizhen Liu, Lianming Liao, Zhiyun Cao, Xuzheng Chen, Jian Du

Pages: 754-760 Published online on: 28 December 2016
Open Access

ARRB1 enhances the chemosensitivity of lung cancer through the mediation of DNA damage response

Hongchang Shen, Liguang Wang, Jiangang Zhang, Wei Dong, Tiehong Zhang, Yang Ni, Hongxin Cao, Kai Wang, Yun Li, Yibing Wang, Jiajun Du

Pages: 761-767 Published online on: 28 December 2016
Open Access

Elevated IQGAP1 and CDC42 levels correlate with tumor malignancy of human glioma

Xiaobo Cui, Laixiao Song, Yunfei Bai, Yaping Wang, Boqian Wang, Wei Wang

Pages: 768-776 Published online on: 29 December 2016

Delphinidin inhibits angiogenesis through the suppression of HIF-1α and VEGF expression in A549 lung cancer cells

Mun-Hyeon Kim, Yun-Jeong Jeong, Hyun-Ji Cho, Hyang-Sook Hoe, Kwan-Kyu Park, Yoon-Yub Park, Yung Hyun Choi, Cheorl-Ho Kim, Hyeun-Wook Chang, Young-Ja Park, Il-Kyung Chung, Young-Chae Chang

Pages: 777-784 Published online on: 07 December 2016

High concordance rate of KRAS/BRAF mutations and MSI-H between primary colorectal cancer and corresponding metastases

Kenji Fujiyoshi, Gou Yamamoto, Akemi Takahashi, Yoshiko Arai, Mina Yamada, Miho Kakuta, Kensei Yamaguchi, Yoshito Akagi, Yoji Nishimura, Hirohiko Sakamoto, Kiwamu Akagi

Pages: 785-792 Published online on: 15 December 2016

2-Methoxyestradiol inhibits the proliferation and migration and reduces the radioresistance of nasopharyngeal carcinoma CNE-2 stem cells via NF-κB/HIF-1 signaling pathway inactivation and EMT reversal

Shun-Long Wu, Ya-Jun Li, Kui Liao, Lei Shi, Na Zhang, Shuang Liu, Yao-Yao Hu, Shao-Lin Li, Ying Wang

Pages: 793-802 Published online on: 14 December 2016

MicroRNA-194 suppresses prostate cancer migration and invasion by downregulating human nuclear distribution protein

Qi Kong, Xu-Shen Chen, Tian Tian, Xiang-You Xia, Peilin Xu

Pages: 803-812 Published online on: 08 December 2016

ELK3 promotes the migration and invasion of liver cancer stem cells by targeting HIF-1α

Joon Ho Lee, Wonhee Hur, Sung Woo Hong, Jung-Hee Kim, Sung Min Kim, Eun Byul Lee, Seung Kew Yoon

Pages: 813-822 Published online on: 07 December 2016

miR-134 suppresses the migration and invasion of non‑small cell lung cancer by targeting ITGB1

Qin Qin, Furong Wei, Jianbo Zhang, Baosheng Li

Pages: 823-830 Published online on: 03 January 2017

High-mobility group box 1 is overexpressed in cervical carcinoma and promotes cell invasion and migration in vitro

Xiaoao Pang, Yao Zhang, Shulan Zhang

Pages: 831-840 Published online on: 14 December 2016

Propofol induces proliferation partially via downregulation of p53 protein and promotes migration via activation of the Nrf2 pathway in human breast cancer cell line MDA-MB-231

Chao Meng, Linlin Song, Juan Wang, Di Li, Yanhong Liu, Xiaoguang Cui

Pages: 841-848 Published online on: 23 December 2016

Bcl-2 overexpression contributes to laryngeal carcinoma cell survival by forming a complex with Hsp90β

Sai Li, Jincheng Li, Tian Hu, Chuhong Zhang, Xiu Lv, Sha He, Hanxing Yan, Yixi Tan, Meiling Wen, Mingsheng Lei, Jianhong Zuo

Pages: 849-856 Published online on: 07 December 2016

DEK protein overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma

Jie Sun, Fangfang Bi, Yang Yang, Yuan Zhang, Aihua Jin, Jinzi Li, Zhenhua Lin

Pages: 857-864 Published online on: 08 December 2016

Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF-κB signaling pathway

Huanhuan Chen, Yuechun Huang, Junbin Huang, Lizhen Lin, Gang Wei

Pages: 865-870 Published online on: 07 December 2016

Lentiviral-mediated overexpression of KCTD12 inhibits the proliferation of human uveal melanoma OCM-1 cells

Lifu Luo, Jizhe Cui, Zhitong Feng, Yana Li, Mengdi Wang, Yong Cai, Yazhen Wu, Jingji Jin

Pages: 871-878 Published online on: 16 December 2016

DNALK2 inhibits the proliferation and invasiveness of breast cancer MDA-MB-231 cells through the Smad-dependent pathway

Ke Wang, Xiaoxiao Sun, Hong Lei Feng, Chang Fei, Yan Zhang

Pages: 879-886 Published online on: 30 December 2016

Promoter methylation attenuates SHP1 expression and function in patients with primary central nervous system lymphoma

Jing Liu, Yaming Wang, Xuefei Sun, Nan Ji, Shengjun Sun, Yajie Wang, Fusheng Liu, Qu Cui, Chen Wang, Yuanbo Liu

Pages: 887-894 Published online on: 08 December 2016

Luteolin suppresses the metastasis of triple-negative breast cancer by reversing epithelial-to-mesenchymal transition via downregulation of β-catenin expression

Dan Lin, Ge Kuang, Jingyuan Wan, Xiang Zhang, Hongzhong Li, Xia Gong, Hongyuan Li

Pages: 895-902 Published online on: 12 December 2016

High expression of RAB43 predicts poor prognosis and is associated with epithelial-mesenchymal transition in gliomas

Ming-Zhi Han, Bin Huang, An-Jing Chen, Xin Zhang, Ran Xu, Jian Wang, Xin-Gang Li

Pages: 903-912 Published online on: 03 January 2017

MicroRNA-138-5p controls sensitivity of nasopharyngeal carcinoma to radiation by targeting EIF4EBP1

Wei Gao, Jacky Wei Kei Lam, John Zeng-Hong Li, Si-Qi Chen, Raymond King-Yin Tsang, Jimmy Yu-Wai Chan, Thian-Sze Wong

Pages: 913-920 Published online on: 04 January 2017

CXCR4 promotes cisplatin-resistance of non-small cell lung cancer in a CYP1B1-dependent manner

Songping Xie, Zhenbo Tu, Jie Xiong, Ganjun Kang, Lina Zhao, Weidong Hu, Haiyan Tan, Kingsley Miyanda Tembo, Qianshan Ding, Xinzhou Deng, Jie Huang, Qiuping Zhang

Pages: 921-928 Published online on: 02 December 2016

Expression of glia maturation factor γ is associated with colorectal cancer metastasis and its downregulation suppresses colorectal cancer cell migration and invasion in vitro

Huili Wang, Zhijiang Chen, Hongen Chang, Xiaoping Mu, Wenyu Deng, Zhaohu Yuan, Fang Yao, Yan Liu, Rongjia Mai, Bingyi Wu

Pages: 929-936 Published online on: 09 January 2017

Lung cancer gene therapy: Transferrin and hyaluronic acid dual ligand-decorated novel lipid carriers for targeted gene delivery

Bin Zhang, Yueying Zhang, Dongmei Yu

Pages: 937-944 Published online on: 07 December 2016

miRNA-301a induces apoptosis of chronic myelogenous leukemia cells by directly targeting TIMP2/ERK1/2 and AKT pathways

Xianbao Huang, Ling Qi, Wei Lu, Gangping Yang, Yan Chen, Rongyan Zhang, Jia Rao, Dexiang Ji, Ruibin Huang, Guoan Chen

Pages: 945-952 Published online on: 22 December 2016

Combined effects of atorvastatin and aspirin on growth and apoptosis in human prostate cancer cells

Yan He, Huarong Huang, Chelsea Farischon, Dongli Li, Zhiyun Du, Kun Zhang, Xi Zheng, Susan Goodin

Pages: 953-960 Published online on: 04 January 2017

hsa-miR-631 resensitizes bortezomib-resistant multiple myeloma cell lines by inhibiting UbcH10

Hao Xi, Lu Li, Juan Du, Ran An, Rong Fan, Jing Lu, Yin-Xiang Wu, Shu-Xie Wu, Jian Hou, Li-Ming Zhao

Pages: 961-968 Published online on: 14 December 2016

Argininosuccinate lyase interacts with cyclin A2 in cytoplasm and modulates growth of liver tumor cells

Yu-Hsuan Hung, Hau-Lun Huang, Wei-Ching Chen, Meng-Chi Yen, Chien-Yu Cho, Tzu-Yang Weng, Chih-Yang Wang, Yi-Ling Chen, Li-Tzong Chen, Ming-Derg Lai

Pages: 969-978 Published online on: 23 December 2016

Expression pattern of DKK3, dickkopf WNT signaling pathway inhibitor 3, in the malignant progression of oral submucous fibrosis

Shanghui Zhou, Yun Zhu, Mubarak Mashrah, Xinyu Zhang, Zhijing He, Zhigang Yao, Chunye Zhang, Feng Guo, Yongjie Hu, Chenping Zhang

Pages: 979-985 Published online on: 08 December 2016

Expression of the promyelocytic leukemia protein without the nuclear localization signal as a novel diagnostic marker for acute promyelocytic leukemia

Ting Xu, Xiao-Qun Yang, Kai-Ling Jiang, Hui Wang, Peng-Peng Ma, Liang Zhong, Bei-Zhong Liu

Pages: 986-994 Published online on: 09 January 2017

Formulation of temozolomide-loaded nanoparticles and their targeting potential to melanoma cells

Guan Jiang, Ronghua Li, Jianqin Tang, Yafeng Ma, Xiaoyang Hou, Chunsheng Yang, Wenwen Guo, Yong Xin, Yanqun Liu

Pages: 995-1001 Published online on: 29 December 2016

Escin induces apoptosis in human renal cancer cells through G2/M arrest and reactive oxygen species-modulated mitochondrial pathways

Sheau-Yun Yuan, Chen-Li Cheng, Shian-Shiang Wang, Hao-Chung Ho, Kun-Yuan Chiu, Chuan-Shu Chen, Cheng-Che Chen, Ming-Yuh Shiau, Yen-Chuan Ou

Pages: 1002-1010 Published online on: 03 January 2017

Suppression of PTEN/AKT signaling decreases the expression of TUBB3 and TOP2A with subsequent inhibition of cell growth and induction of apoptosis in human breast cancer MCF-7 cells via ATP and caspase-3 signaling pathways

Zhenhua Yang, Ying Liu, Changzheng Shi, Yuqin Zhang, Rongzhao Lv, Rong Zhang, Qian Wang, Yiming Wang

Pages: 1011-1019 Published online on: 09 January 2017

A novel, rapid point-of-care test for lung cancer patients to detect epidermal growth factor receptor gene mutations by using real-time droplet-PCR and fresh liquid cytology specimens

Shiho Asaka, Akihiko Yoshizawa, Kazuyuki Matsuda, Akemi Yamaguchi, Hiroshi Yamamoto, Takayuki Shiina, Rie Nakata, Kaoru Ogawa, Meng Zhang, Takayuki Honda

Pages: 1020-1026 Published online on: 02 December 2016

Testin is a tumor suppressor in non-small cell lung cancer

Ming Wang, Qian Wang, Wen-Jia Peng, Jun-Feng Hu, Zu-Yi Wang, Hao Liu, Li-Nian Huang

Pages: 1027-1035 Published online on: 14 December 2016

Regorafenib induces extrinsic and intrinsic apoptosis through inhibition of ERK/NF-κB activation in hepatocellular carcinoma cells

Jai-Jen Tsai, Po-Jung Pan, Fei-Ting Hsu

Pages: 1036-1044 Published online on: 20 December 2016

Overexpression of SOX18 promotes prostate cancer progression via the regulation of TCF1, c-Myc, cyclin D1 and MMP-7

Huaqi Yin, Zhengzuo Sheng, Xiaowei Zhang, Yiqing Du, Caipeng Qin, Huixin Liu, Yaojun Dun, Qi Wang, Chengyue Jin, Yanhui Zhao, Tao Xu

Pages: 1045-1051 Published online on: 02 December 2016

miR-367 promotes the proliferation and invasion of non-small cell lung cancer via targeting FBXW7

Jing Xu, Weibing Wu, Jun Wang, Chenjun Huang, Wei Wen, Fei Zhao, Xinfeng Xu, Xianglong Pan, Wei Wang, Quan Zhu, Liang Chen

Pages: 1052-1058 Published online on: 14 December 2016

Elevated expression of TrpC5 and GLUT1 is associated with chemoresistance in colorectal cancer

Teng Wang, Kuan Ning, Ting-Xun Lu, Dong Hua

Pages: 1059-1065 Published online on: 15 December 2016

Identifying the optimal gene and gene set in hepatocellular carcinoma based on differential expression and differential co-expression algorithm

Li-Yang Dong, Wei-Zhong Zhou, Jun-Wei Ni, Wei Xiang, Wen-Hao Hu, Chang Yu, Hai-Yan Li

Pages: 1066-1074 Published online on: 23 December 2016

miR-196b/miR-1290 participate in the antitumor effect of resveratrol via regulation of IGFBP3 expression in acute lymphoblastic leukemia

Wei Zhou, Shunqing Wang, Yi Ying, Ruiqing Zhou, Ping Mao

Pages: 1075-1083 Published online on: 15 December 2016

Ellagic acid inhibits human glioblastoma growth in vitro and in vivo

Dongliang Wang, Qianxue Chen, Yinqiu Tan, Baohui Liu, Chao Liu

Pages: 1084-1092 Published online on: 22 December 2016

miR-375 inhibits cancer stem cell phenotype and tamoxifen resistance by degrading HOXB3 in human ER-positive breast cancer

Hui Fu, Lei Fu, Chao Xie, Wen-Shu Zuo, Yan-Song Liu, Mei-Zhu Zheng, Jin-Ming Yu

Pages: 1093-1099 Published online on: 09 January 2017

Death-associated protein kinase 3 controls the tumor progression of A549 cells through ERK MAPK/c-Myc signaling

Satoru Kake, Tatsuya Usui, Takashi Ohama, Hideyuki Yamawaki, Koichi Sato

Pages: 1100-1106 Published online on: 09 January 2017

HELQ reverses the malignant phenotype of osteosarcoma cells via CHK1-RAD51 signaling pathway

Dong Ning Liu, Yun Fei Zhou, Ai Fen Peng, Xin Hua Long, Xuan Yin Chen, Zhi Li Liu, Hong Xia

Pages: 1107-1113 Published online on: 20 December 2016

CXCL7 promotes proliferation and invasion of cholangiocarcinoma cells

Qian Guo, Zhixiang Jian, Baoqing Jia, Liang Chang

Pages: 1114-1122 Published online on: 12 December 2016

miR-24-3p regulates bladder cancer cell proliferation, migration, invasion and autophagy by targeting DEDD

Guoqiang Yu, Zhaohui Jia, Zhongling Dou

Pages: 1123-1131 Published online on: 16 December 2016

Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells

Bo Wang, Xin-Huai Zhao

Pages: 1132-1140 Published online on: 08 December 2016

Inhibition of casein kinase 2 prevents growth of human osteosarcoma

Kengo Takahashi, Takao Setoguchi, Arisa Tsuru, Yoshinobu Saitoh, Satoshi Nagano, Yasuhiro Ishidou, Shingo Maeda, Tatsuhiko Furukawa, Setsuro Komiya

Pages: 1141-1147 Published online on: 09 December 2016

miR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion

Shun-Jie Chen, Ping Wu, Li-Jing Sun, Bo Zhou, Wei Niu, Shuang Liu, Fu-Jun Lin, Geng-Ru Jiang

Pages: 1148-1158 Published online on: 07 December 2016

MicroRNA-302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang

Pages: 1159-1167 Published online on: 15 December 2016

Thioridazine elicits potent antitumor effects in colorectal cancer stem cells

Chen Zhang, Ping Gong, Pengfei Liu, Ning Zhou, Yulai Zhou, Yi Wang

Pages: 1168-1174 Published online on: 14 December 2016

Combined analysis of gene expression, miRNA expression and DNA methylation profiles of osteosarcoma

Wenpeng Zhang, Shiliang Han, Kang Sun

Pages: 1175-1181 Published online on: 15 December 2016

Silencing of GP73 inhibits invasion and metastasis via suppression of epithelial-mesenchymal transition in hepatocellular carcinoma

Ying Yang, Qiang Liu, Hua Zhang, Huarong Zhao, Ruin Mao, Zhipeng Li, Sha Ya, Chunli Jia, Yongxing Bao

Pages: 1182-1188 Published online on: 04 January 2017

Downregulation of the N-myc downstream regulated gene 1 is related to enhanced proliferation, invasion and migration of pancreatic cancer

Gang Cen, Kundong Zhang, Jun Cao, Zhengjun Qiu

Pages: 1189-1195 Published online on: 05 January 2017

Silencing of Forkhead box D1 inhibits proliferation and migration in glioma cells

Yuan-Feng Gao, Tao Zhu, Xiao-Yuan Mao, Chen-Xue Mao, Ling Li, Ji-Ye Yin, Hong-Hao Zhou, Zhao-Qian Liu

Pages: 1196-1202 Published online on: 02 January 2017

Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway

Feng Gao, Gang Deng, Wenbin Liu, Kechao Zhou, Ming Li

Pages: 1203-1211 Published online on: 03 January 2017

17β-estradiol-induced growth of triple-negative breast cancer cells is prevented by the reduction of GPER expression after treatment with gefitinib

Rainer Girgert, Günter Emons, Carsten Gründker

Pages: 1212-1218 Published online on: 08 December 2016

Anticancer effect of luteolin is mediated by downregulation of TAM receptor tyrosine kinases, but not interleukin-8, in non-small cell lung cancer cells

Youn Ju Lee, Taeho Lim, Min Su Han, Sun-Hwa Lee, Suk‑Hwan Baek, Hong-Yan Nan, Chuhee Lee

Pages: 1219-1226 Published online on: 23 December 2016

MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma

Jiejing Zhou, Yanjun Zhang, Yuhong Qi, Dequan Yu, Qiuju Shao, Jun Liang

Pages: 1227-1234 Published online on: 05 December 2016

Fibroblast growth factor 18 promotes proliferation and migration of H460 cells via the ERK and p38 signaling pathways

Taotao Chen, Weiyue Gong, Haishan Tian, Haijun Wang, Shenghui Chu, Jisheng Ma, Huanhuan Yang, Jiliang Cheng, Min Liu, Xiaokun Li, Chao Jiang

Pages: 1235-1242 Published online on: 07 December 2016

Isomahanine induces endoplasmic reticulum stress and simultaneously triggers p38 MAPK-mediated apoptosis and autophagy in multidrug-resistant human oral squamous cell carcinoma cells

Tanyarath Utaipan, Anan Athipornchai, Apichart Suksamrarn, Surasak Chunsrivirot, Warangkana Chunglok

Pages: 1243-1252 Published online on: 04 January 2017

Co-delivery of doxorubicin and pH-sensitive curcumin prodrug by transferrin-targeted nanoparticles for breast cancer treatment

Tongxing Cui, Sihao Zhang, Hong Sun

Pages: 1253-1260 Published online on: 02 January 2017

ACY-1215 accelerates vemurafenib induced cell death of BRAF-mutant melanoma cells via induction of ER stress and inhibition of ERK activation

Ueihuei Peng, Zhihao Wang, Sa Pei, Yunchao Ou, Pengchao Hu, Wanhong Liu, Jiquan Song

Pages: 1270-1276 Published online on: 28 December 2016

Gallic acid induces HeLa cell death via increasing GSH depletion rather than ROS levels

Woo Hyun Park

Pages: 1277-1283 Published online on: 23 December 2016
Journal Cover

February 2017
Volume 37 Issue 2

Print ISSN: 1021-335X
Online ISSN: 1791-2431

2015 Impact Factor: 2.486
Ranked #31/211 Oncology
(total number of cites)

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