Reduced mitochondrial response sensitivity is involved in the anti‑apoptotic effect of dexmedetomidine pretreatment in cardiomyocytes

  • Authors:
    • Xiaojian Weng
    • Xiaodan Zhang
    • Xiaofei Lu
    • Jin Wu
    • Shitong Li
  • View Affiliations

  • Published online on: January 12, 2018     https://doi.org/10.3892/ijmm.2018.3384
  • Pages:2328-2338
Metrics: HTML 0 views | PDF 0 views     Cited By (CrossRef): 0 citations

Abstract

Dexmedetomidine is a commonly used α2-adreno­ceptor agonist, which affects various organs, including providing beneficial effects on the heart. However, the mechanism underlying the cardiac benefit remains to be fully elucidated. In the present study, it was demonstrated that dexmedetomidine pretreatment on primary cultured rat cardiomyocytes protected against reactive oxygen species (ROS)‑induced apoptosis. In terms of the potential mechanism, it was demonstrated that dexmedetomidine inhibited mitochondrial biogenesis and mitochondrial respiratory complexes, but with increased coupling efficiency. However, dexmedetomidine upregulated mitochondrial membrane potential (Δψm) and resisted against the loss of Δψm induced by carbonilcyanide p‑triflouromethoxyphenylhydrazone. Due to the importance of mitochondria affecting ROS, the present study investigated the dexmedetomidine‑suppressed mitochondrial response to H2O2 stimulation, which was explained by suppressed ROS levels and the suppression of the increased oxygen consumption rate. Results demonstrated for the first time, to the best of our knowledge, a novel protective mechanism for dexmedetomidine on cardiomyocytes through the attenuated response of mitochondria towards H2O2, which had a protective effect against ROS‑induced apoptosis.

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April 2018
Volume 41 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

2016 Impact Factor: 2.341
Ranked #21/128 Medicine Research and Experimental
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APA
Weng, X., Zhang, X., Lu, X., Wu, J., & Li, S. (2018). Reduced mitochondrial response sensitivity is involved in the anti‑apoptotic effect of dexmedetomidine pretreatment in cardiomyocytes. International Journal of Molecular Medicine, 41, 2328-2338. https://doi.org/10.3892/ijmm.2018.3384
MLA
Weng, X., Zhang, X., Lu, X., Wu, J., Li, S."Reduced mitochondrial response sensitivity is involved in the anti‑apoptotic effect of dexmedetomidine pretreatment in cardiomyocytes". International Journal of Molecular Medicine 41.4 (2018): 2328-2338.
Chicago
Weng, X., Zhang, X., Lu, X., Wu, J., Li, S."Reduced mitochondrial response sensitivity is involved in the anti‑apoptotic effect of dexmedetomidine pretreatment in cardiomyocytes". International Journal of Molecular Medicine 41, no. 4 (2018): 2328-2338. https://doi.org/10.3892/ijmm.2018.3384