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The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.

  • Authors:
    • T Sano
    • E C Gabazza
    • H Zhou
    • H Takeya
    • T Hayashi
    • M Ido
    • Y Adachi
    • A Uchida
    • K Suzuki

  • View Affiliations

  • Published online on: December 1, 1999     https://doi.org/10.3892/ijo.15.6.1197
  • Pages: 1197-1400
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The coagulation system plays a role in tumor invasion and metastasis. Prothrombin was previously found to stimulate the motility of melanoma cells. We compared the effect of prothrombin and thrombin on cell motility, calcium influx and actin stress filament contraction in highly metastatic osteosarcoma LM8 cells. Prothrombin and thrombin stimulated chemotaxis and chemokinesis of LM8 cells in a dose-dependent manner. Calcium influx was significantly increased after stimulation with thrombin and prothrombin. Thrombin and prothrombin markedly stimulated actin contraction in LM8 cells. Hirudin inhibited the effects of thrombin but not those of prothrombin. Prothrombin appears to stimulate cell locomotion, actin contraction, calcium influx in LM8 cells by different mechanism from thrombin.

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Journal Cover

Dec 1999
Volume 15 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Sano T, Gabazza E, Zhou H, Takeya H, Hayashi T, Ido M, Adachi Y, Uchida A and Suzuki K: The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.. Int J Oncol 15: 1197-1400, 1999.
APA
Sano, T., Gabazza, E., Zhou, H., Takeya, H., Hayashi, T., Ido, M. ... Suzuki, K. (1999). The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.. International Journal of Oncology, 15, 1197-1400. https://doi.org/10.3892/ijo.15.6.1197
MLA
Sano, T., Gabazza, E., Zhou, H., Takeya, H., Hayashi, T., Ido, M., Adachi, Y., Uchida, A., Suzuki, K."The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.". International Journal of Oncology 15.6 (1999): 1197-1400.
Chicago
Sano, T., Gabazza, E., Zhou, H., Takeya, H., Hayashi, T., Ido, M., Adachi, Y., Uchida, A., Suzuki, K."The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.". International Journal of Oncology 15, no. 6 (1999): 1197-1400. https://doi.org/10.3892/ijo.15.6.1197