Open Access

Rho GTPases as therapeutic targets in cancer (Review)

  • Authors:
    • G. A. Cardama
    • N. Gonzalez
    • J. Maggio
    • P. Lorenzano Menna
    • D. E. Gomez
  • View Affiliations

  • Published online on: August 9, 2017     https://doi.org/10.3892/ijo.2017.4093
0

Abstract

Rho GTPases are key molecular switches controlling the transduction of external signals to cytoplasmic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases in cancer. The aim of the present review is to describe the cellular functions regulated by these proteins with focus in deregulated signals present in malignant tumors. Finally, we describe the state of the art in search of different experimental therapeutic strategies with Rho GTPases as molecular targets.

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Copy and paste a formatted citation
APA
Cardama, G.A., Gonzalez, N., Maggio, J., Menna, P.L., & Gomez, D.E. (1899). Rho GTPases as therapeutic targets in cancer (Review). International Journal of Oncology, 0, 0-0. https://doi.org/10.3892/ijo.2017.4093
MLA
Cardama, G. A., Gonzalez, N., Maggio, J., Menna, P. L., Gomez, D. E."Rho GTPases as therapeutic targets in cancer (Review)". International Journal of Oncology 0.0 (1899): 0-0.
Chicago
Cardama, G. A., Gonzalez, N., Maggio, J., Menna, P. L., Gomez, D. E."Rho GTPases as therapeutic targets in cancer (Review)". International Journal of Oncology 0, no. 0 (1899): 0-0. https://doi.org/10.3892/ijo.2017.4093