[18F]FDG-PET/CT and MRI for initial pelvic lymph node staging in patients with cervical carcinoma: The potential usefulness of [18F]FDG-PET/MRI

  • Authors:
    • Philip Anner
    • Marius Mayerhöfer
    • Wolfgang Wadsak
    • Silvana Geleff
    • Robert Dudczak
    • Alexander Haug
    • Marcus Hacker
    • Georgios Karanikas
  • View Affiliations

  • Published online on: January 12, 2018     https://doi.org/10.3892/ol.2018.7775
  • Pages:3951-3956
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Abstract

The current study aimed to determine the optimum diagnostic imaging technique out of magnetic resonance imaging (MRI), 18F‑fludeoxyglucose positron emission tomography/computed tomography ([18F]FDG‑PET/CT, otherwise known as PET/CT) and [18F]FDG‑PET/MRI (otherwise known as PET/MRI) for the pelvic lymph node staging (N‑staging) of untreated cervical carcinoma (CC). A total of 27 patients were included in the present study. All patients had undergone pre‑treatment with PET/CT and MRI ≤45 days prior to undergoing a lymphadenectomy. The results from PET (separated from PET/CT), MRI and the statistically combined results of (virtual) PET/MRI were compared to those from histological analyses (the gold standard). A per‑patient‑based analysis of the detection of pelvic lymph node metastases indicated that PET/MRI had a sensitivity of 64%. The specificity of PET/CT and MRI were 69 and 62%, respectively. The positive predictive value (PPV) was 69 and 64% for PET/CT and MRI, respectively. The negative predictive value (NPV) was 64 and 62% for PET/CT and MRI, respectively. The sensitivity of the PET‑guided PET/MRI and the MRI‑guided PET/MRI was 64% for both. The specificity of the PET‑guided PET/MRI and the MRI‑guided PET/MRI was 77 and 62%, respectively. The PPV was 75% for PET‑guided PET/MRI and 64% for MRI‑guided PET/MRI, and the NPV was 67 and 62%, respectively. PET/CT and the virtual PET/MRI exhibited the same low sensitivity (64%). PET/MRI exhibited slightly better results than PET/CT regarding specificity (77 vs. 69%, respectively), PPV (75 vs. 69%, respectively) and NPV (67 vs. 64%, respectively). The results of the present study suggested that PET/CT and MRI are not optimal diagnostic modalities, and that PET/MRI does not necessarily lead to better results than PET/CT, in the pelvic N-staging of CC.

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March 2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
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APA
Anner, P., Mayerhöfer, M., Wadsak, W., Geleff, S., Dudczak, R., Haug, A. ... Karanikas, G. (2018). [18F]FDG-PET/CT and MRI for initial pelvic lymph node staging in patients with cervical carcinoma: The potential usefulness of [18F]FDG-PET/MRI. Oncology Letters, 15, 3951-3956. https://doi.org/10.3892/ol.2018.7775
MLA
Anner, P., Mayerhöfer, M., Wadsak, W., Geleff, S., Dudczak, R., Haug, A., Hacker, M., Karanikas, G."[18F]FDG-PET/CT and MRI for initial pelvic lymph node staging in patients with cervical carcinoma: The potential usefulness of [18F]FDG-PET/MRI". Oncology Letters 15.3 (2018): 3951-3956.
Chicago
Anner, P., Mayerhöfer, M., Wadsak, W., Geleff, S., Dudczak, R., Haug, A., Hacker, M., Karanikas, G."[18F]FDG-PET/CT and MRI for initial pelvic lymph node staging in patients with cervical carcinoma: The potential usefulness of [18F]FDG-PET/MRI". Oncology Letters 15, no. 3 (2018): 3951-3956. https://doi.org/10.3892/ol.2018.7775