Expression profile of N-cadherin differs from other classical cadherins as a prognostic marker in renal cell carcinoma

  • Authors:
    • Toru Shimazui
    • Takahiro Kojima
    • Mizuki Onozawa
    • Masahiko Suzuki
    • Taeko Asano
    • Hideyuki Akaza
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  • Published online on: May 1, 2006     https://doi.org/10.3892/or.15.5.1181
  • Pages: 1181-1184
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Abstract

Renal cell carcinomas (RCCs) primarily express cadherin-6 and N-cadherin rather than E-cadherin, and the aberrant expression of cadherin-6 correlates with a poor prognosis in patients with E-cadherin-absent RCC. However, the role of N-cadherin in RCC has not yet been elucidated. In this study, we analyze the expression pattern of N-cadherin in surgical RCC specimens and discuss the function of N-cadherin in RCC together with a re-evaluation of our previous study. Forty-six surgically resected RCC specimens were used in this study. The expression and localization of E-cadherin and N-cadherin in surgical specimens were demonstrated by immunohistochemistry. Correlations between the expression pattern of each cadherin, pathological parameters and patient survival were analyzed. RCC specimens expressed N-cadherin as a normal pattern despite the elevation of tumor grade, and patients with N-cadherin-normal RCC had a poorer prognosis than those with N-cadherin-abnormal RCC. Since our previous study showed that N-cadherin only functioned in cell attachment when E-cadherin and cadherin-6 were impaired, N-cadherin plays a different role from E-cadherin or cadherin-6 in RCC and may be associated with the aggressiveness and malignant potential of RCC.

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May 2006
Volume 15 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Shimazui T, Kojima T, Onozawa M, Suzuki M, Asano T and Akaza H: Expression profile of N-cadherin differs from other classical cadherins as a prognostic marker in renal cell carcinoma. Oncol Rep 15: 1181-1184, 2006.
APA
Shimazui, T., Kojima, T., Onozawa, M., Suzuki, M., Asano, T., & Akaza, H. (2006). Expression profile of N-cadherin differs from other classical cadherins as a prognostic marker in renal cell carcinoma. Oncology Reports, 15, 1181-1184. https://doi.org/10.3892/or.15.5.1181
MLA
Shimazui, T., Kojima, T., Onozawa, M., Suzuki, M., Asano, T., Akaza, H."Expression profile of N-cadherin differs from other classical cadherins as a prognostic marker in renal cell carcinoma". Oncology Reports 15.5 (2006): 1181-1184.
Chicago
Shimazui, T., Kojima, T., Onozawa, M., Suzuki, M., Asano, T., Akaza, H."Expression profile of N-cadherin differs from other classical cadherins as a prognostic marker in renal cell carcinoma". Oncology Reports 15, no. 5 (2006): 1181-1184. https://doi.org/10.3892/or.15.5.1181