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Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells

  • Authors:
    • Chan Zhu
    • Yuqin Pan
    • Bangshun He
    • Bo Wang
    • Yongfei Xu
    • Lili Qu
    • Qian Bao
    • Fuliang Tian
    • Shukui Wang

  • View Affiliations

  • Published online on: December 9, 2010     https://doi.org/10.3892/or.2010.1088
  • Pages: 425-432
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Abstract

CD147, also named extracelluar matrix metalloproteinase inducer (EMMPRIN), is a member of the immunoglobulin family and a glycoprotein enriched on the surface of tumor cells, which promotes invasion, metastasis, growth and survival of malignant cells, and is known to confer resistance to some chemotherapeutic drugs. To determine the possible role of CD147 in the invasive properties of laryngeal carcinoma, we used an RNA interference approach to silence CD147 expression in the Hep2 cell line at high levels of CD147 expression. Our results showed that CD147 expression was significantly impeded at both mRNA and protein levels, which resulted in a decrease of the Hep2 invasion activity in vitro and tumorigenicity in nude mice. The suppression of CD147 expression also sensitized cells to cisplatin. Our current results indicated that CD147 was a laryngeal carcinoma-related gene and CD147 might be a potential target for therapeutic anti-cancer drugs.

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February 2011
Volume 25 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Zhu C, Pan Y, He B, Wang B, Xu Y, Qu L, Bao Q, Tian F and Wang S: Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells. Oncol Rep 25: 425-432, 2011.
APA
Zhu, C., Pan, Y., He, B., Wang, B., Xu, Y., Qu, L. ... Wang, S. (2011). Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells. Oncology Reports, 25, 425-432. https://doi.org/10.3892/or.2010.1088
MLA
Zhu, C., Pan, Y., He, B., Wang, B., Xu, Y., Qu, L., Bao, Q., Tian, F., Wang, S."Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells". Oncology Reports 25.2 (2011): 425-432.
Chicago
Zhu, C., Pan, Y., He, B., Wang, B., Xu, Y., Qu, L., Bao, Q., Tian, F., Wang, S."Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells". Oncology Reports 25, no. 2 (2011): 425-432. https://doi.org/10.3892/or.2010.1088