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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 1997 Volume 4 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1997 Volume 4 Issue 4

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Article

Alterations of cholesteryl ester metabolism characteristic for cancer

  • Authors:
    • J Hradec

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    Affiliations: Affliations not specified
  • Pages: 759-763
    |
    Published online on: July 1, 1997
       https://doi.org/10.3892/or.4.4.759
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Abstract

Earlier as well as recent evidence obtained in our laboratory is reviewed indicating that specific changes in cholesteryl ester metabolism are related to tumor growth. Some properties of cholesteryl 14-methylhexadecanoate, an unknown lipid discovered and identified in our laboratory are described and its fundamental role as an essential cofactor in protein synthesis is emphasized. Increased quantities of this ester are present in tissues of tumor-bearing animals and the elevation of its level in serum is proportional to the tumor growth. Evidence has been presented that it may be a useful and reliable marker of malignant tumors in humans. This compound is synthesized in liver cells by enzymes that were recently purified to homogeneity from rat liver. The activity of these enzymes is significantly enhanced in tumor-bearing rats in a close proportion to the tumor growth. Activity of these preparations from normal rat liver may be greatly enhanced by the addition in vitro of serum from cancer patients. Since the enzymes are of lecithin-cholesterol acyl transferase type, apparently cancer serum contains some peculiar molecular species of these phospholipids. Because these lipids may be specific products of tumor cells, attempts are now in progress in this laboratory to identify them and the possibility is studied for their utilization as specific tumor markers.

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Copy and paste a formatted citation
Spandidos Publications style
Hradec J: Alterations of cholesteryl ester metabolism characteristic for cancer. Oncol Rep 4: 759-763, 1997.
APA
Hradec, J. (1997). Alterations of cholesteryl ester metabolism characteristic for cancer. Oncology Reports, 4, 759-763. https://doi.org/10.3892/or.4.4.759
MLA
Hradec, J."Alterations of cholesteryl ester metabolism characteristic for cancer". Oncology Reports 4.4 (1997): 759-763.
Chicago
Hradec, J."Alterations of cholesteryl ester metabolism characteristic for cancer". Oncology Reports 4, no. 4 (1997): 759-763. https://doi.org/10.3892/or.4.4.759
Copy and paste a formatted citation
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Spandidos Publications style
Hradec J: Alterations of cholesteryl ester metabolism characteristic for cancer. Oncol Rep 4: 759-763, 1997.
APA
Hradec, J. (1997). Alterations of cholesteryl ester metabolism characteristic for cancer. Oncology Reports, 4, 759-763. https://doi.org/10.3892/or.4.4.759
MLA
Hradec, J."Alterations of cholesteryl ester metabolism characteristic for cancer". Oncology Reports 4.4 (1997): 759-763.
Chicago
Hradec, J."Alterations of cholesteryl ester metabolism characteristic for cancer". Oncology Reports 4, no. 4 (1997): 759-763. https://doi.org/10.3892/or.4.4.759
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