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4-Chlorobenzoyl berbamine induces apoptosis and G2/M cell cycle arrest through the PI3K/Akt and NF-κB signal pathway in lymphoma cells

  • Authors:
    • Hua-Ping Du
    • Jia-Kun Shen
    • Min Yang
    • Yun-Qui Wang
    • Xiang-Qui Yuan
    • Qiu-Ling Ma
    • Jie Jin

  • View Affiliations

  • Published online on: March 1, 2010     https://doi.org/10.3892/or_00000688
  • Pages: 709-716
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Berbamine is an herbal compound derived from Berberis amurensis, which is used in Chinese traditional medicine. However, few studies have investigated this anti-tumor effect or the underlying mechanisms of berbamine on lymphoma cells. We investigate the effect, as well as the mechanism of action, of 4-chlorobenzoyl berbamine (BBD9) on Raji, L428, Namalwa and Jurkat lymphoma cells lines. Our findings show that BBD9 inhibits cell proliferation and induces cell apoptosis in lymphoma cell lines as well as G2/M cell cycle arrest through PI3K/Akt and NF-κB signaling pathways in a caspase-dependent manner. These results may provide new insights into the treatment of lymphoma.

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Journal Cover

March 2010
Volume 23 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Du H, Shen J, Yang M, Wang Y, Yuan X, Ma Q and Jin J: 4-Chlorobenzoyl berbamine induces apoptosis and G2/M cell cycle arrest through the PI3K/Akt and NF-κB signal pathway in lymphoma cells. Oncol Rep 23: 709-716, 2010.
APA
Du, H., Shen, J., Yang, M., Wang, Y., Yuan, X., Ma, Q., & Jin, J. (2010). 4-Chlorobenzoyl berbamine induces apoptosis and G2/M cell cycle arrest through the PI3K/Akt and NF-κB signal pathway in lymphoma cells. Oncology Reports, 23, 709-716. https://doi.org/10.3892/or_00000688
MLA
Du, H., Shen, J., Yang, M., Wang, Y., Yuan, X., Ma, Q., Jin, J."4-Chlorobenzoyl berbamine induces apoptosis and G2/M cell cycle arrest through the PI3K/Akt and NF-κB signal pathway in lymphoma cells". Oncology Reports 23.3 (2010): 709-716.
Chicago
Du, H., Shen, J., Yang, M., Wang, Y., Yuan, X., Ma, Q., Jin, J."4-Chlorobenzoyl berbamine induces apoptosis and G2/M cell cycle arrest through the PI3K/Akt and NF-κB signal pathway in lymphoma cells". Oncology Reports 23, no. 3 (2010): 709-716. https://doi.org/10.3892/or_00000688