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Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells

  • Authors:
    • Jie-Hyun Kim
    • Yeun Jung Choi
    • Sang Hun Lee
    • Hyun Soo Shin
    • In Ohk Lee
    • Yu Jin Kim
    • Hyunki Kim
    • Woo Ick Yang
    • Hoguen Kim
    • Yong Chan Lee

  • View Affiliations

  • Published online on: June 1, 2010     https://doi.org/10.3892/or_00000791
  • Pages: 1523-1528
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

This study aimed to investigate the effect of Helicobacter pylori (H. pylori) infection on the sonic Hedgehog (Shh) signaling in gastric cancer. Shh, Patched (Ptch), and transcription factor Gli1 were overexpressed in H. pylori-infected gastric cancer cells. The oncoprotein, CagA positive H. pylori resulted in significantly higher Shh expression. Pretreatment with MG-132 or PDTC significantly lowered Shh expression. Significant overexpression of Shh and Gli1 were noted in H. pylori-infected compared to non-infected gastric cancer tissues. Conclusively, H. pylori activated the Shh signaling pathway in CagA-dependent manner partly through the NF-κB pathway in gastric cancer cells.

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Journal Cover

June 2010
Volume 23 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Kim J, Choi YJ, Lee SH, Shin HS, Lee IO, Kim YJ, Kim H, Yang WI, Kim H, Lee YC, Lee YC, et al: Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells . Oncol Rep 23: 1523-1528, 2010.
APA
Kim, J., Choi, Y.J., Lee, S.H., Shin, H.S., Lee, I.O., Kim, Y.J. ... Lee, Y.C. (2010). Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells . Oncology Reports, 23, 1523-1528. https://doi.org/10.3892/or_00000791
MLA
Kim, J., Choi, Y. J., Lee, S. H., Shin, H. S., Lee, I. O., Kim, Y. J., Kim, H., Yang, W. I., Kim, H., Lee, Y. C."Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells ". Oncology Reports 23.6 (2010): 1523-1528.
Chicago
Kim, J., Choi, Y. J., Lee, S. H., Shin, H. S., Lee, I. O., Kim, Y. J., Kim, H., Yang, W. I., Kim, H., Lee, Y. C."Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells ". Oncology Reports 23, no. 6 (2010): 1523-1528. https://doi.org/10.3892/or_00000791