search button

Expression of 53BP1 as a cisplatin-resistant marker in patients with lung adenocarcinomas

  • Authors:
    • Tan-Chen Lai
    • Kuan-Chih Chow
    • Tze-Yi Lin
    • I-Ping Chiang
    • Hsin-Yuan Fang
    • Chih-Yi Chen
    • Shu-Peng Ho

  • View Affiliations

  • Published online on: August 1, 2010     https://doi.org/10.3892/or_00000862
  • Pages: 321-328
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

DNA repair is one of the major causes of spontaneous drug and radiation resistance in patients with lung adenocarcinomas (LADC). 53BP1 is a mediator that relays signals from DNA damage sensors and activates various effectors for the DNA repair and cell survival. In this study we investigated the clinical and biological significance of 53BP1. Expression of 53BP1 was detected by immunoblotting and immunohistochemistry. Our data showed that 53BP1 was detected in 166 (75.8%) of 219 LADC patients. Expression of 53BP1 correlated with tumor stage, cigarette smoking, lymphovascular invasion and poor clinical outcome. In vitro, increased 53BP1 expression elevated drug resistance, and silencing of 53BP1 expression reduced cisplatin resistance. Our results suggest that 53BP1 expression plays an important role in cisplatin resistance and predicts the prognosis for LADC.

Related Articles

Journal Cover

August 2010
Volume 24 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Lai T, Chow K, Lin T, Chiang I, Fang H, Chen C and Ho S: Expression of 53BP1 as a cisplatin-resistant marker in patients with lung adenocarcinomas . Oncol Rep 24: 321-328, 2010.
APA
Lai, T., Chow, K., Lin, T., Chiang, I., Fang, H., Chen, C., & Ho, S. (2010). Expression of 53BP1 as a cisplatin-resistant marker in patients with lung adenocarcinomas . Oncology Reports, 24, 321-328. https://doi.org/10.3892/or_00000862
MLA
Lai, T., Chow, K., Lin, T., Chiang, I., Fang, H., Chen, C., Ho, S."Expression of 53BP1 as a cisplatin-resistant marker in patients with lung adenocarcinomas ". Oncology Reports 24.2 (2010): 321-328.
Chicago
Lai, T., Chow, K., Lin, T., Chiang, I., Fang, H., Chen, C., Ho, S."Expression of 53BP1 as a cisplatin-resistant marker in patients with lung adenocarcinomas ". Oncology Reports 24, no. 2 (2010): 321-328. https://doi.org/10.3892/or_00000862