Alexander A. Shtil
Blokhin National Medical Center of Oncology, Russian Federation
- Orcid: 0000-0001-6469-0221
- Publications: N/A
- Citations: N/A
- Keywords: antitumor drug resistance, transcriptional regulation in cancer, medicinal chemistry
Short Bio
- Alexander Shtil, MD, PhD Head, Laboratory of Tumor Cell Death Blokhin Cancer Center, Moscow, Russia Phone: +7(499)612-7834 E-mail: shtilaa@yahoo.com Dr. A. Shtil received his MD degree in Orenburg State Medical Institute and PhD in Moscow Research Institute of Otorhinolaryngology. In 1994-2002 he worked in the University of Illinois at Chicago, Lee Moffitt Cancer Center and Sloan-Kettering Cancer Institute, studying the mechanisms of multidrug resistance and altered drug response in cancer (with I.Roninson, W.Dalton and K.Scotto). After returning home he established a new laboratory of tumor cell death at Blokhin Cancer Center with broad interests in cancer biology. The laboratory is studying the molecular mechanisms of cytocidal effects of small molecular weight compounds as perspective anticancer drug candidates. Our particular interest is novel DNA ligands, including the derivatives of anthraquinone and porphyrins that target the double helix and complex DNA structures. We also investigate the anti-apoptotic and pro-proliferation protein kinases of Pim, DYRK and Clk families as druggable targets. International cooperation includes the European Consortium “Protein kinases – Novel Drug Targets of Post Genomic Era” and contacts with groups in the United States, France, Japan and Taiwan. In 2018-2000 A.Shtil is a group leader in the Megagrant ‘CDK8-mediated transcriptional reprogramming: interface of biology and medicine’ with I. Roninson (USA) as a chief scientist. Dr. A. Shtil organized tumor biology laboratories at the Institute of Gene Biology, Moscow State University, Moscow Engineering and Physics Institute and ITMO University at Saint-Petersburg. Dr. Shtil has authored more than 200 scientific papers, review articles and a number of patents. He is member of editorial boards in four international journals.
