Open Access

Evaluation of the effect of salmon nasal proteoglycan on biomarkers for cartilage metabolism in individuals with knee joint discomfort: A randomized double‑blind placebo‑controlled clinical study

  • Authors:
    • Akihito Tomonaga
    • Tatsuji Takahashi
    • Yuka Tsuda Tanaka
    • Makoto Tsuboi
    • Kumie Ito
    • Isao Nagaoka
  • View Affiliations

  • Published online on: May 11, 2017     https://doi.org/10.3892/etm.2017.4454
  • Pages: 115-126
  • Copyright: © Tomonaga et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A randomized double-blind placebo-controlled clinical trial was conducted to evaluate the chondroprotective action of salmon nasal cartilage proteoglycan on joint health. The effect of oral administration of proteoglycan (10 mg/day) on cartilage metabolism was evaluated in individuals with knee joint discomfort but without diagnosis of knee osteoarthritis. The average age of patients was 52.6±1.1 years old. The effect of proteoglycan was evaluated by analyzing markers for type II collagen degradation (C1,2C) and synthesis (PIICP), and the ratio of type II collagen degradation to synthesis. The results indicated that the change in C1,2C levels significantly differed in the proteoglycan group compared with the placebo group following 16 weeks intervention among subjects with high levels of knee pain and physical dysfunction (total score of Japan Knee Osteoarthritis Measure ≥41) and subjects with constant knee pain (both P<0.05). There was a greater increase in PIICP levels in the proteoglycan group than the placebo group following intervention, although this difference was not significant in both sets of patients. Thus, the C1,2C/PIICP ratios decreased in the proteoglycan group, whereas they slightly increased in the placebo group following the intervention. Furthermore, no test supplement‑related adverse events were observed during the intervention. Therefore, oral administration of salmon nasal cartilage proteoglycan at a dose of 10 mg/day may exert a chondroprotective action in subjects with knee joint discomfort. This effect was achieved by improving cartilage metabolism (reducing type II collagen degradation and enhancing type II collagen synthesis), without causing apparent adverse effects.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Tomonaga A, Takahashi T, Tanaka YT, Tsuboi M, Ito K and Nagaoka I: Evaluation of the effect of salmon nasal proteoglycan on biomarkers for cartilage metabolism in individuals with knee joint discomfort: A randomized double‑blind placebo‑controlled clinical study. Exp Ther Med 14: 115-126, 2017.
APA
Tomonaga, A., Takahashi, T., Tanaka, Y.T., Tsuboi, M., Ito, K., & Nagaoka, I. (2017). Evaluation of the effect of salmon nasal proteoglycan on biomarkers for cartilage metabolism in individuals with knee joint discomfort: A randomized double‑blind placebo‑controlled clinical study. Experimental and Therapeutic Medicine, 14, 115-126. https://doi.org/10.3892/etm.2017.4454
MLA
Tomonaga, A., Takahashi, T., Tanaka, Y. T., Tsuboi, M., Ito, K., Nagaoka, I."Evaluation of the effect of salmon nasal proteoglycan on biomarkers for cartilage metabolism in individuals with knee joint discomfort: A randomized double‑blind placebo‑controlled clinical study". Experimental and Therapeutic Medicine 14.1 (2017): 115-126.
Chicago
Tomonaga, A., Takahashi, T., Tanaka, Y. T., Tsuboi, M., Ito, K., Nagaoka, I."Evaluation of the effect of salmon nasal proteoglycan on biomarkers for cartilage metabolism in individuals with knee joint discomfort: A randomized double‑blind placebo‑controlled clinical study". Experimental and Therapeutic Medicine 14, no. 1 (2017): 115-126. https://doi.org/10.3892/etm.2017.4454