Effect of the polyphenol composition BP‑C3 on haematological and intestinal indicators of 5‑fluorouracil toxicity in mice

Panchenko,Andrey   V.; Fedoros,Elena   I.; Pigarev,Sergey  E.; Maydin,Mikhail  A.; Gubareva,Ekaterina   A.; Yurova,Maria   N.; Kireeva,Galina  S.; Lanskikh,Galina  P.; Tyndyk,Margarita  L.; Anisimov,Vladimir   N.

doi:10.3892/etm.2018.5782

Effect of the polyphenol composition BP‑C3 on haematological and intestinal indicators of 5‑fluorouracil toxicity in mice

Authors:
- Andrey V. Panchenko
- Elena I. Fedoros
- Sergey E. Pigarev
- Mikhail A. Maydin
- Ekaterina A. Gubareva
- Maria N. Yurova
- Galina S. Kireeva
- Galina P. Lanskikh
- Margarita L. Tyndyk
- Vladimir N. Anisimov
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Affiliations: Department of Carcinogenesis and Oncogerontology, N.N. Petrov National Medical Research Center of Oncology, Saint‑Petersburg 197758, Russia, Nobel, Ltd., Saint‑Petersburg 192012, Russia
Published online on: January 22, 2018 https://doi.org/10.3892/etm.2018.5782
Pages: 3124-3132

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Abstract

BP‑C3 is a formulation, which comprises lignin‑derived polyphenolic composition of benzenepolycarboxylic acids (BP‑Cx‑1) with iron complex, selenium, ascorbic acid and retinol, and possesses geroprotective activity. The present study examined the effect of BP‑C3 (80 mg/kg, administered 18 times in total by gavage) on the development of haematological and intestinal manifestations of toxicity following 5‑fluorouracil (5‑FU; 150 mg/kg, administered once via intravenous injection) administration in outbred male Swiss‑H Rappolovo (SHR) mice. The use of BP‑C3 on therapeutic and preventative/therapeutic schedules demonstrated that it was protective against the toxic effect of 5‑FU exerted on the lymphopoietic organs. Administering ВР‑С3 24 h after 5‑FU (therapeutic schedule) had an effect on the recovery of leukopoiesis and prevented anaemia in the mice. In the mice that received 5‑FU and 5‑FU with BP‑C3 prior to and following administration of the chemotherapeutic agent (preventative/therapeutic schedule), mild anaemia developed by day 7. Administration of BP‑C3 without 5‑FU did not affect blood cell differentiation in the mice. Thus, BP‑C3, depending on the administration schedule, had different effects on the haematological parameters of haematopoietic organs and peripheral blood in mice exposed to 5‑FU. BP‑C3 promoted intestinal crypt survival when administered on the preventative/therapeutic and therapeutic schedules, suggesting that the formulation protects the epithelium of the small intestine against damage by 5‑FU.

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