The role of endocannabinoids in visceral hyposensitivity induced by rapid eye movement sleep deprivation in rats: Regional differences

  • Authors:
    • Liyun Wang
    • Ting Yang
    • Wei Qian
    • Xiaohua Hou
  • View Affiliations

  • Published online on: November 5, 2010     https://doi.org/10.3892/ijmm.2010.547
  • Pages: 119-126
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Visceral hypersensitivity is one of the most important mechanisms of functional gastrointestinal diseases. Our previous studies have shown that rapid eye movement (REM) sleep deprivation (REMSD) decreases visceral sensitivity in rats, but the mechanisms involved in this effect, have not yet been clarified. In this study, we investigated the role of the CNS and peripheral endocannabinoids in visceral hyposensitivity induced by REMSD. Animals were randomly divided into the cage-yoked (YC), the REMSD group, which suffered from REMSD for 48 h, and the group with the interventions of Rimonabant after REMSD. The visceral sensitivity of all the groups was assessed, and the expressions of cannabinoid receptor (CB1R), fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL) in the CNS and gut regions, were detected. We demonstrate that REMSD decreases visceral sensitivity in rats and that the Rimonabant intervention antagonizes this effect. The expression of CB1R in the CNS region was significantly higher in the REMSD compared to the YC group. We did not see similar results in the gut. At the same time, the expressions of FAAH and MGL in the CNS and colon, excluding the iliac terminus, were lower in the REMSD compared to the YC group. Endocannabinoids are involved in the mechanism of visceral hyposensitivity in rats induced by REMSD. Possibly those in the CNS play the main role in this activity.

Related Articles

Journal Cover

January 2011
Volume 27 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Yang T, Qian W and Hou X: The role of endocannabinoids in visceral hyposensitivity induced by rapid eye movement sleep deprivation in rats: Regional differences. Int J Mol Med 27: 119-126, 2011.
APA
Wang, L., Yang, T., Qian, W., & Hou, X. (2011). The role of endocannabinoids in visceral hyposensitivity induced by rapid eye movement sleep deprivation in rats: Regional differences. International Journal of Molecular Medicine, 27, 119-126. https://doi.org/10.3892/ijmm.2010.547
MLA
Wang, L., Yang, T., Qian, W., Hou, X."The role of endocannabinoids in visceral hyposensitivity induced by rapid eye movement sleep deprivation in rats: Regional differences". International Journal of Molecular Medicine 27.1 (2011): 119-126.
Chicago
Wang, L., Yang, T., Qian, W., Hou, X."The role of endocannabinoids in visceral hyposensitivity induced by rapid eye movement sleep deprivation in rats: Regional differences". International Journal of Molecular Medicine 27, no. 1 (2011): 119-126. https://doi.org/10.3892/ijmm.2010.547