PINK1 signaling in mitochondrial homeostasis and in aging (Review)

  • Authors:
    • Yasuko Kitagishi
    • Noriko Nakano
    • Mako Ogino
    • Mayuko Ichimura
    • Akari Minami
    • Satoru Matsuda
  • View Affiliations

  • Published online on: December 12, 2016     https://doi.org/10.3892/ijmm.2016.2827
  • Pages:3-8
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Abstract

Mitochondrial dysfunction is involved in the pathology of Parkinson's disease, an age-associated neurodegenerative disorder. Phosphatase and tensin homolog (PTEN)-induced putative kinase protein 1 (PINK1) is responsible for the most common form of recessive Parkinson's disease. PINK1 is a mitochondrial kinase that is involved in mitrochondrial quality control and promotes cell survival. PINK1 has been shown to protect against neuronal cell death induced by oxidative stress. Accordingly, PINK1 deficiency is associated with mitochondrial dysfunction as well as increased oxidative cellular stress and subsequent neuronal cell death. In addition, several mitochondrial chaperone proteins have been shown to be substrates of the PINK1 kinase. In this review, we discuss recent studies concerning the signaling cascades and molecular mechanisms involved in the process of mitophagy, which is implicated in neurodegeneration and in related aging associated with oxidative stress. Particular attention will be given to the molecular mechanisms proposed to explain the effects of natural compounds and/or food ingredients against oxidative stress. Knowledge of the molecular mechanisms involved in this cellular protection could be critical for developing treatments to prevent and control excessive progression of neurodegenerative disorders.

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January 2017
Volume 39 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

2016 Impact Factor: 2.341
Ranked #21/128 Medicine Research and Experimental
(total number of cites)

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APA
Kitagishi, Y., Nakano, N., Ogino, M., Ichimura, M., Minami, A., & Matsuda, S. (2017). PINK1 signaling in mitochondrial homeostasis and in aging (Review). International Journal of Molecular Medicine, 39, 3-8. https://doi.org/10.3892/ijmm.2016.2827
MLA
Kitagishi, Y., Nakano, N., Ogino, M., Ichimura, M., Minami, A., Matsuda, S."PINK1 signaling in mitochondrial homeostasis and in aging (Review)". International Journal of Molecular Medicine 39.1 (2017): 3-8.
Chicago
Kitagishi, Y., Nakano, N., Ogino, M., Ichimura, M., Minami, A., Matsuda, S."PINK1 signaling in mitochondrial homeostasis and in aging (Review)". International Journal of Molecular Medicine 39, no. 1 (2017): 3-8. https://doi.org/10.3892/ijmm.2016.2827