Open Access

Role of stem cell-derived exosomes in cancer (Review)

  • Authors:
    • Junyi Wu
    • Zhen Qu
    • Zi‑Wei Fei
    • Jun‑Hua Wu
    • Chun‑Ping Jiang
  • View Affiliations

  • Published online on: March 7, 2017     https://doi.org/10.3892/ol.2017.5824
  • Pages:2855-2866
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Exosomes are small, extracellular membrane-enclosed vesicles that contain a variety of molecules, including proteins, DNA, mRNA and non-coding RNA; these vesicles have been defined as new tools for intercellular communication between cells. Numerous types of cells, including stem cells, secrete exosomes into the extracellular environment, and are significant communicators in the tumor microenvironment. Stem cells are a unique cell population defined by their ability to indefinitely self-renew, differentiate into a variety of cell lines, and form clonal cell populations. Stem cells also secrete large amounts of exosomes, which have demonstrated great potential in a variety of diseases. Increasing evidence has revealed that the mechanism of interaction between stem cells and human tumor cells involves the exchange of biological material through exosomes. In this review, the latest developments in the role of stem cell‑derived exosomes in cancer are highlighted.

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Journal Cover

May 2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

2015 Impact Factor: 1.482
Ranked #97/211 Oncology
(total number of cites)

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APA
Wu, J., Qu, Z., Fei, Z., Wu, J., & Jiang, C. (2017). Role of stem cell-derived exosomes in cancer (Review). Oncology Letters, 13, 2855-2866. https://doi.org/10.3892/ol.2017.5824
MLA
Wu, J., Qu, Z., Fei, Z., Wu, J., Jiang, C."Role of stem cell-derived exosomes in cancer (Review)". Oncology Letters 13.5 (2017): 2855-2866.
Chicago
Wu, J., Qu, Z., Fei, Z., Wu, J., Jiang, C."Role of stem cell-derived exosomes in cancer (Review)". Oncology Letters 13, no. 5 (2017): 2855-2866. https://doi.org/10.3892/ol.2017.5824