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Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer

  • Authors:
    • Krzysztof Siemianowicz
    • Jan Gminski
    • Wojciech Garczorz
    • Natalia Slabiak
    • Malgorzata Goss
    • Marek Machalski
    • Helena Magiera-Molendowska

  • View Affiliations

  • Published online on: September 1, 2003     https://doi.org/10.3892/or.10.5.1341
  • Pages: 1341-1344
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Abstract

Two mutations of methylenetetrahydrofolate reductase (MTHFR) gene (C677T and A1298C) may lead to a decreased activity of the enzyme. These mutations may change a risk of some cancers. We evaluated these two polymorphisms of MTHFR in patients with small cell lung cancer (SCLC) and non-small cell lung cancer (NCSCL). All lung cancer patients had statistically significantly higher percentage of MTHFR 677TT genotype in comparison with non-cancer controls. There were no statistically significant differences in the distribution of MTHFR 1298 genotypes. Neither of the polymorphisms presented any statistically significant differences between SCLC and NSCLC.

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September-October 2003
Volume 10 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Siemianowicz K, Gminski J, Garczorz W, Slabiak N, Goss M, Machalski M and Magiera-Molendowska H: Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer. Oncol Rep 10: 1341-1344, 2003.
APA
Siemianowicz, K., Gminski, J., Garczorz, W., Slabiak, N., Goss, M., Machalski, M., & Magiera-Molendowska, H. (2003). Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer. Oncology Reports, 10, 1341-1344. https://doi.org/10.3892/or.10.5.1341
MLA
Siemianowicz, K., Gminski, J., Garczorz, W., Slabiak, N., Goss, M., Machalski, M., Magiera-Molendowska, H."Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer". Oncology Reports 10.5 (2003): 1341-1344.
Chicago
Siemianowicz, K., Gminski, J., Garczorz, W., Slabiak, N., Goss, M., Machalski, M., Magiera-Molendowska, H."Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer". Oncology Reports 10, no. 5 (2003): 1341-1344. https://doi.org/10.3892/or.10.5.1341