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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2005 Volume 13 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa

  • Authors:
    • Noriko Kodama
    • Akihiro Asakawa
    • Akio Inui
    • Yuki Masuda
    • Hiroaki Nanba

  • View Affiliations / Copyright

    Affiliations: Department of Microbial Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyama-kitamachi, Higashinada-ku, Kobe 658-8558, Japan. n-kodama@kobepharma-u.ac.jp
  • Pages: 497-502
    |
    Published online on: March 1, 2005
       https://doi.org/10.3892/or.13.3.497
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Abstract

In innate immunity, activated natural killer (NK) cells attack and damage pathogens such as bacteria and virus without restriction by the MHC antigen. NK cells activated by IL-12 have been reported to recognize and kill tumor cells in perforin-mediated apoptosis. We have reported that D-Fraction, a polysaccharide extracted from the maitake mushroom (Grifola frondosa), activates macrophages, dendritic cells, and T cells and inhibits the growth of tumor cells. However, the effects of D-Fraction on NK cell function in the innate immune response are not well known. In the present study, we administered D-Fraction to MM-46 mammary tumor-bearing C3H/HeJ mice intraperitoneally for 3 consecutive days and investigated its effects on the activation and cytotoxicity of NK cells. D-Fraction significantly enhanced the cytotoxicity against NK-sensitive YAC-1 cells and the expression of CD223 on NK cells. D-Fraction also increased the expression of CD86 on macrophages. In addition, the levels of IL-12 in the culture supernatant of whole spleen cells and in serum increased, compared with the control corresponding to an increase in expression of IL-12 receptor βI on NK cells. These results suggest that D-Fraction enhances the cytotoxicity of NK cells through the production of IL-12 by macrophages activated by D-Fraction.

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Copy and paste a formatted citation
Spandidos Publications style
Kodama N, Asakawa A, Inui A, Masuda Y and Nanba H: Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa. Oncol Rep 13: 497-502, 2005.
APA
Kodama, N., Asakawa, A., Inui, A., Masuda, Y., & Nanba, H. (2005). Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa. Oncology Reports, 13, 497-502. https://doi.org/10.3892/or.13.3.497
MLA
Kodama, N., Asakawa, A., Inui, A., Masuda, Y., Nanba, H."Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa". Oncology Reports 13.3 (2005): 497-502.
Chicago
Kodama, N., Asakawa, A., Inui, A., Masuda, Y., Nanba, H."Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa". Oncology Reports 13, no. 3 (2005): 497-502. https://doi.org/10.3892/or.13.3.497
Copy and paste a formatted citation
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Spandidos Publications style
Kodama N, Asakawa A, Inui A, Masuda Y and Nanba H: Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa. Oncol Rep 13: 497-502, 2005.
APA
Kodama, N., Asakawa, A., Inui, A., Masuda, Y., & Nanba, H. (2005). Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa. Oncology Reports, 13, 497-502. https://doi.org/10.3892/or.13.3.497
MLA
Kodama, N., Asakawa, A., Inui, A., Masuda, Y., Nanba, H."Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa". Oncology Reports 13.3 (2005): 497-502.
Chicago
Kodama, N., Asakawa, A., Inui, A., Masuda, Y., Nanba, H."Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa". Oncology Reports 13, no. 3 (2005): 497-502. https://doi.org/10.3892/or.13.3.497
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