E-cadherin increases squamous cell carcinoma antigen expression through phosphatidylinositol-3 kinase-Akt pathway in squamous cell carcinoma cell lines

  • Authors:
    • Tatsushi Nakagawa
    • Akihiro Murakami
    • Mayumi Torii
    • Shugo Nawata
    • Osamu Takeda
    • Norihiro Sugino
  • View Affiliations

  • Published online on: July 1, 2007     https://doi.org/10.3892/or.18.1.175
  • Pages: 175-179
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Abstract

Squamous cell carcinoma antigen (SCCA) has been used for the management of squamous cell carcinoma, especially for evaluating therapeutic effects and monitoring recurrence. It has been reported that SCCA has several biological activities and influences behavior of cancer cells. E-cadherin is a cell adhesion molecule and plays important roles in the process of cancer invasion and metastasis. Our previous studies have shown that blockage of E-cadherin action by anti-E-cadherin antibody treatment suppresses SCCA production in squamous cell carcinoma cells. This finding strongly suggests that E-cadherin regulates SCCA expression. The present study was, therefore, undertaken to investigate the correlation between E-cadherin and SCCA2. For this purpose, E-cadherin cDNA was transfected into squamous cell carcinoma cell lines, SiHa and SKG IIIa. Overexpression of E-cadherin increased SCCA2 expression together with cell aggregation. We also examined the involvement of phosphatidylinositol 3-kinase (PI3K)-Akt pathway, which is one of major signaling pathways from E-cadherin. E-cadherin transfection increased phosphorylated Akt expression concomitantly with the increase in SCCA2 expression, and the increased SCCA2 expression was inhibited by a PI3K inhibitor. In conclusion, SCCA2 is up-regulated by E-cadherin through PI3K-Akt pathway, suggesting that SCCA2, as well as E-cadherin, may be involved in the regulation of cancer behavior.

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July 2007
Volume 18 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Nakagawa T, Murakami A, Torii M, Nawata S, Takeda O and Sugino N: E-cadherin increases squamous cell carcinoma antigen expression through phosphatidylinositol-3 kinase-Akt pathway in squamous cell carcinoma cell lines. Oncol Rep 18: 175-179, 2007.
APA
Nakagawa, T., Murakami, A., Torii, M., Nawata, S., Takeda, O., & Sugino, N. (2007). E-cadherin increases squamous cell carcinoma antigen expression through phosphatidylinositol-3 kinase-Akt pathway in squamous cell carcinoma cell lines. Oncology Reports, 18, 175-179. https://doi.org/10.3892/or.18.1.175
MLA
Nakagawa, T., Murakami, A., Torii, M., Nawata, S., Takeda, O., Sugino, N."E-cadherin increases squamous cell carcinoma antigen expression through phosphatidylinositol-3 kinase-Akt pathway in squamous cell carcinoma cell lines". Oncology Reports 18.1 (2007): 175-179.
Chicago
Nakagawa, T., Murakami, A., Torii, M., Nawata, S., Takeda, O., Sugino, N."E-cadherin increases squamous cell carcinoma antigen expression through phosphatidylinositol-3 kinase-Akt pathway in squamous cell carcinoma cell lines". Oncology Reports 18, no. 1 (2007): 175-179. https://doi.org/10.3892/or.18.1.175