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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2012 Volume 27 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2012 Volume 27 Issue 1

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Article

Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade

  • Authors:
    • Kiyotada Watanabe
    • Syu-Ichi Kanno
    • Ayako Tomizawa
    • Shin Yomogida
    • Masaaki Ishikawa

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aobaku, Sendai 981-8553, Japan
  • Pages: 204-209
    |
    Published online on: October 12, 2011
       https://doi.org/10.3892/or.2011.1498
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Abstract

Flavonoids are naturally occurring antioxidants, with several flavonoids shown to have chemopreventive effects on cancer. We investigated the effects of the flavonoid acacetin on human T cell leukemia Jurkat cells. Acacetin inhibited the proliferation of Jurkat cells by inducing apoptosis in a concentration- and time-dependent manner. Acacetin-induced cell death was characterized by changes in nuclear and cell morphology. Treatment of Jurkat cells with acacetin also induced caspase-3, -8 and -9 activities in a time-dependent manner. Acacetin-induced apoptosis was blocked by a broad-spectrum caspase inhibitor, a caspase-3 inhibitor and a caspase-8 inhibitor, but not by a caspase-9 inhibitor. In addition, acacetin promoted the expression of FAF1, phosphor-FADD, Apaf-1 and cytochrome c. Acacetin-induced apoptosis was also accompanied by upregulation of Bax, and downregulation of Bcl-2. Taken together, these results suggest that acacetin may induce apoptosis in T cell leukemia cells, possibly by activating the Fas-mediated pathway. These findings may help in designing cancer therapeutic and chemopreventive agents.

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Copy and paste a formatted citation
Spandidos Publications style
Watanabe K, Kanno S, Tomizawa A, Yomogida S and Ishikawa M: Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade. Oncol Rep 27: 204-209, 2012.
APA
Watanabe, K., Kanno, S., Tomizawa, A., Yomogida, S., & Ishikawa, M. (2012). Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade. Oncology Reports, 27, 204-209. https://doi.org/10.3892/or.2011.1498
MLA
Watanabe, K., Kanno, S., Tomizawa, A., Yomogida, S., Ishikawa, M."Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade". Oncology Reports 27.1 (2012): 204-209.
Chicago
Watanabe, K., Kanno, S., Tomizawa, A., Yomogida, S., Ishikawa, M."Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade". Oncology Reports 27, no. 1 (2012): 204-209. https://doi.org/10.3892/or.2011.1498
Copy and paste a formatted citation
x
Spandidos Publications style
Watanabe K, Kanno S, Tomizawa A, Yomogida S and Ishikawa M: Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade. Oncol Rep 27: 204-209, 2012.
APA
Watanabe, K., Kanno, S., Tomizawa, A., Yomogida, S., & Ishikawa, M. (2012). Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade. Oncology Reports, 27, 204-209. https://doi.org/10.3892/or.2011.1498
MLA
Watanabe, K., Kanno, S., Tomizawa, A., Yomogida, S., Ishikawa, M."Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade". Oncology Reports 27.1 (2012): 204-209.
Chicago
Watanabe, K., Kanno, S., Tomizawa, A., Yomogida, S., Ishikawa, M."Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade". Oncology Reports 27, no. 1 (2012): 204-209. https://doi.org/10.3892/or.2011.1498
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