Open Access

Exosomes: New players in cancer (Review)

  • Authors:
    • Wei Guo
    • Yibo Gao
    • Ning Li
    • Fei Shao
    • Chunni Wang
    • Pan Wang
    • Zhenlin Yang
    • Renda Li
    • Jie He
  • View Affiliations

  • Published online on: June 13, 2017     https://doi.org/10.3892/or.2017.5714
  • Pages:665-675
0

Abstract

The past decade has witnessed an exponential increase in research on exosomes. For many years considered to be extracellular debris, exosomes are now considered important mediators in intercellular communication. The capability of exosomes to transfer proteins, DNA, mRNA, as well as non-coding RNAs has made them an attractive focus of research into the pathogenesis of different diseases, including cancer. Increasing evidence suggests that tumor cells release a large sum of exosomes, which may not only influence proximal tumor cells and stromal cells in local microenvironment, but also can exert systemic effects when participating in blood circulation. In this study, we review the current understanding on this topic. The literature outlines two broad facets of exosomes in cancer: 1) promotion of tumor growth, tumorigenesis, tumor angiogenesis, tumor immune escape, drug resistance, and metastasis and 2) their role as promising biomarkers for cancer diagnosis and even as potential treatment targets for cancer patients.

Related Articles

Journal Cover

August 2017
Volume 38 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Guo, W., Gao, Y., Li, N., Shao, F., Wang, C., Wang, P. ... He, J. (2017). Exosomes: New players in cancer (Review). Oncology Reports, 38, 665-675. https://doi.org/10.3892/or.2017.5714
MLA
Guo, W., Gao, Y., Li, N., Shao, F., Wang, C., Wang, P., Yang, Z., Li, R., He, J."Exosomes: New players in cancer (Review)". Oncology Reports 38.2 (2017): 665-675.
Chicago
Guo, W., Gao, Y., Li, N., Shao, F., Wang, C., Wang, P., Yang, Z., Li, R., He, J."Exosomes: New players in cancer (Review)". Oncology Reports 38, no. 2 (2017): 665-675. https://doi.org/10.3892/or.2017.5714