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Molecular analysis of CDKN2 (p16) in gliomas associated with clinical data

  • Authors:
    • Patricia De Souza Nascimento
    • Carla Mendes Maciel
    • Marcia Tie Kawamura
    • Jose Antonio Oliveira
    • Anselmo Teixeira
    • Maria da Gloria Costa Carvalho
    • Gilda Alves

  • View Affiliations

  • Published online on: September 1, 2001     https://doi.org/10.3892/or.8.5.1039
  • Pages: 1039-1043
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Abstract

We analyzed alterations in CDKN2 in gliomas from an ethically mixed population and correlated the results with patients clinical data. We screened for methylation at CDKN2 and for microsatellite instability (MSI) and loss of heterozygosity (LOH) in the region 9p21-22 using 4 markers. We found: 3/30 (10%) cases with CDKN2-methylated gliomas; an average of 4% of MSI; and 24.5% of LOH in the region 9p21-22. Methylation of CDKN2 was only detected in patients showing high-grade gliomas with short survival. MSI and LOH in the region 9p21-22 were detected in patients showing high-grade gliomas with short survival and in one patient with a recurrent low-grade astrocytoma grade II who died from the disease after 3 years, indicating that such alterations represent poor prognosis.

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September-October 2001
Volume 8 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
De Souza Nascimento P, Mendes Maciel C, Tie Kawamura M, Oliveira JA, Teixeira A, da Gloria Costa Carvalho M and Alves G: Molecular analysis of CDKN2 (p16) in gliomas associated with clinical data. Oncol Rep 8: 1039-1043, 2001.
APA
De Souza Nascimento, P., Mendes Maciel, C., Tie Kawamura, M., Oliveira, J.A., Teixeira, A., da Gloria Costa Carvalho, M., & Alves, G. (2001). Molecular analysis of CDKN2 (p16) in gliomas associated with clinical data. Oncology Reports, 8, 1039-1043. https://doi.org/10.3892/or.8.5.1039
MLA
De Souza Nascimento, P., Mendes Maciel, C., Tie Kawamura, M., Oliveira, J. A., Teixeira, A., da Gloria Costa Carvalho, M., Alves, G."Molecular analysis of CDKN2 (p16) in gliomas associated with clinical data". Oncology Reports 8.5 (2001): 1039-1043.
Chicago
De Souza Nascimento, P., Mendes Maciel, C., Tie Kawamura, M., Oliveira, J. A., Teixeira, A., da Gloria Costa Carvalho, M., Alves, G."Molecular analysis of CDKN2 (p16) in gliomas associated with clinical data". Oncology Reports 8, no. 5 (2001): 1039-1043. https://doi.org/10.3892/or.8.5.1039