Brain magnetic resonance imaging findings in hyperammonemic hepatic encephalopathy: A case series and literature review
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- Published online on: April 11, 2025 https://doi.org/10.3892/br.2025.1976
- Article Number: 98
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Abstract
Hyperammonemic encephalopathy is a life‑threatening condition that can lead to coma and death due to brain edema and intracranial hypertension. The current study presents the clinical and magnetic resonance imaging (MRI) findings of 5 cases of acute hyperammonemic hepatic encephalopathy. MRI images of all 5 patients showed diffuse cortical swelling affecting the frontal, temporal, and parietal lobes, as well as the insular cortex and cingulate gyri. However, the underlying white matter, peri‑rolandic area, and posterior occipital lobe remained unaffected. These specific brain MRI features are more commonly observed in cases with 165 µmol/l or higher ammonia levels, suggesting a potential correlation. Further studies are needed to confirm this association.
