Evaluation of the combined expression of chemokine SDF-1α and its receptor CXCR4 as a prognostic marker for gastric cancer

Lee,Hyo   Jin; Huang,Song   Mei; Kim,Ha   Yon; Oh,Yoon   Suk; Hwang,Ji   Young; Liang,Zhe   Long; Min,Jeong   Ki; Yun,Hwan   Jung; Sul,Ji   Young; Kim,Samyong; Jo,Deog   Yeon; Kim,Jin   Man

doi:10.3892/etm.2011.228

Evaluation of the combined expression of chemokine SDF-1α and its receptor CXCR4 as a prognostic marker for gastric cancer

Authors:
- Hyo Jin Lee
- Song Mei Huang
- Ha Yon Kim
- Yoon Suk Oh
- Ji Young Hwang
- Zhe Long Liang
- Jeong Ki Min
- Hwan Jung Yun
- Ji Young Sul
- Samyong Kim
- Deog Yeon Jo
- Jin Man Kim
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Affiliations: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea, Department of Pathology, Chungnam National University School of Medicine, Daejeon, Republic of Korea, Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea, Department of Surgery, Chungnam National University School of Medicine, Daejeon, Republic of Korea, Department of Pathology and Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, Republic of Korea
Published online on: March 16, 2011 https://doi.org/10.3892/etm.2011.228
Pages: 499-504

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Abstract

Chemokine stromal cell-derived factor (SDF)-1α and its receptor CXC chemokine receptor 4 (CXCR4) have been shown to impact cancer progression. Accumulating evidence suggests that CXCR4 and SDF-1α expression is useful for evaluating the risk of gastric cancer progression. Thus, combined analysis of SDF-1α and CXCR4 should have high prognostic potential as a molecular marker for gastric cancer. We investigated the expression of SDF-1α and CXCR4 using immunohistochemistry in relation to prognosis, clinicopathological features and clinical outcomes in 221 cases of primary gastric cancer. Patients were categorized into three groups according to CXCR4 and SDF-1α expression: high CXCR4/high SDF-1α, low CXCR4/low SDF-1α, and high CXCR4/low SDF-1α – low CXCR4/high SDF-1α. No significant differences were noted in age, gender, histology, tumor location, lymphovascular invasion or proportion of tumor size >5 cm among the three groups. However, high CXCR4/high SDF-1α expression in tumor cells was significantly associated with depth of invasion of the tumor, lymph node involvement, and higher tumor stage compared to tumors with low CXCR4/low SDF-1α expression or high CXCR4/low SDF-1α – low CXCR4/high SDF-1α expression. Furthermore, patients with high CXCR4/high SDF-1α expression had the worst patient prognosis, whereas patients who had low CXCR4/low SDF-1α expression showed the most favorable prognosis. In conclusion, CXCR4 and SDF-1α are useful prognostic factors in gastric cancer, and the combination of high CXCR4 protein expression with high SDF-1α expression suggests a dismal prognosis.

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