Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome

  • Authors:
    • Aurélie Perraud
    • Michelle Nouaille
    • Hussein Akil
    • Daniel Petit
    • François Labrousse
    • Marie-Odile Jauberteau
    • Muriel Mathonnet
  • View Affiliations

  • Published online on: March 21, 2011     https://doi.org/10.3892/etm.2011.242
  • Pages: 491-497
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Abstract

The status of the three retinoic acid receptors (RARs) α, β and γ in human colorectal cancer (CRC) has not as yet been examined. RARs are in part responsible for the actions of the retinoids (vitamin A and its derivatives), which are essential for human health and survival due to their extensive involvement in numerous cellular processes, in particular in epithelial morphology. The present study examined the expression of the three RARs in CRC using immunohisto­chemical analysis of paraffin-embedded tissue sections. RAR expression in tumor (T) and adjacent non-tumor (NT) specimens from stage I (n=6), stage II (n=34), stage III (n=26) and stage IV (n=14) CRC patients was compared with that in normal mucous membranes (n=10) from control individuals. The findings were correlated with tumor grade, treatment response (progression during treatment, remission, chemoresistance) and survival as clinicopathological parameters. RARα and γ expression was decreased with CRC stage in the T tissues (P=0.016 and P=0.052, respectively), suggesting that they may be used as predictive markers. RARβ expression in the NT tissues was associated with a more favorable prognosis (P=0.04). These results provide important information on the tumor microenvironment (the area adjacent to tumor cells).
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May-June 2011
Volume 2 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Perraud A, Nouaille M, Akil H, Petit D, Labrousse F, Jauberteau M and Mathonnet M: Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome. Exp Ther Med 2: 491-497, 2011.
APA
Perraud, A., Nouaille, M., Akil, H., Petit, D., Labrousse, F., Jauberteau, M., & Mathonnet, M. (2011). Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome. Experimental and Therapeutic Medicine, 2, 491-497. https://doi.org/10.3892/etm.2011.242
MLA
Perraud, A., Nouaille, M., Akil, H., Petit, D., Labrousse, F., Jauberteau, M., Mathonnet, M."Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome". Experimental and Therapeutic Medicine 2.3 (2011): 491-497.
Chicago
Perraud, A., Nouaille, M., Akil, H., Petit, D., Labrousse, F., Jauberteau, M., Mathonnet, M."Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome". Experimental and Therapeutic Medicine 2, no. 3 (2011): 491-497. https://doi.org/10.3892/etm.2011.242