HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development (Review)

Kikuchi,Kiyoshi; Uchikado,Hisaaki; Miura,Naoki; Morimoto,Yoko; Ito,Takashi; Tancharoen,Salunya; Miyata,Kei; Sakamoto,Rokudai; Kikuchi,Chiemi; Iida,Narumi; Shiomi,Naoto; Kuramoto,Terukazu; Miyagi,Naohisa; Kawahara,Ko-Ichi

doi:10.3892/etm.2011.310

HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development (Review)

Authors:
- Kiyoshi Kikuchi
- Hisaaki Uchikado
- Naoki Miura
- Yoko Morimoto
- Takashi Ito
- Salunya Tancharoen
- Kei Miyata
- Rokudai Sakamoto
- Chiemi Kikuchi
- Narumi Iida
- Naoto Shiomi
- Terukazu Kuramoto
- Naohisa Miyagi
- Ko-Ichi Kawahara
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Affiliations: Department of Neurosurgery, Yame Public General Hospital, Yame 834-0034, Japan, Department of Neurosurgery, Kurume University School of Medicine, Kurume 830-0011, Japan, Veterinary Teaching Hospital and Laboratory of Veterinary Diagnostic Imaging, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan, Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan, Division of Laboratory and Vascular Medicine, Field of Cardiovascular and Respiratory Disorders, Department of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan, Department of Pharmacology, Faculty of Dentistry, Mahidol University, Rajthevee, Bangkok 10400, Thailand, Department of Rehabilitation, Nishida Koutoku Hospital, Saiki, Oita 876-0047, Japan, Research Laboratory, Kohjin Co., Ltd., Saiki, Oita 876-8580, Japan, Emergency Department, Saiseikai Shiga Hospital, Rittou, Shiga 520-3046, Japan, Department of Neurosurgery, Omuta City General Hospital, Omuta, Fukuoka 836-8567, Japan
Published online on: June 30, 2011 https://doi.org/10.3892/etm.2011.310
Pages: 767-770

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Abstract

Historically, clinical outcomes following spinal cord injury (SCI) have been dismal. Severe SCI leads to devastating neurological deficits, and there is no treatment available that restores the injury-induced loss of function to a degree that an independent life can be guaranteed. To address all the issues associated with SCI, a multidisciplinary approach is required, as it is unlikely that a single approach, such as surgical intervention, pharmacotherapy or cellular transplantation, will suffice. High mobility group box 1 (HMGB1) is an inflammatory cytokine. Various studies have shown that HMGB1 plays a critical role in SCI and that inhibition of HMGB1 release may be a novel therapeutic target for SCI and may support spinal cord repair. In addition, HMGB1 has been associated with graft rejection in the early phase. Therefore, HMGB1 may be a promising therapeutic target for SCI transplant patients. We hypothesize that inhibition of HMGB1 release rescues patients with SCI. Taken together, our findings suggest that anti-HMGB1 monoclonal antibodies or short hairpin RNA-mediated HMGB1 could be administered for spinal cord repair in SCI patients.

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