Association study between polymorphisms of the PARD3 gene and schizophrenia
- Authors:
- Su Kang Kim
- Jong Yoon Lee
- Hae Jeong Park
- Jong Woo Kim
- Joo-Ho Chung
-
View Affiliations
Affiliations: Department of Pharmacology and Kohwang Medical Research Institute, Kyung Hee University, Seoul 130-701, Republic of Korea, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea, Department of Pharmacology and Kohwang Medical Research Institute, Kyung Hee University, Seoul 130-702, Republic of Korea, Department of Neuropsychiatry, School of Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea
- Published online on: February 23, 2012 https://doi.org/10.3892/etm.2012.496
-
Pages:
881-885
Metrics:
Total
Views: 0 (Spandidos Publications: | PMC Statistics:
)
Metrics:
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics:
)
This article is mentioned in:
Abstract
The aim of this study was to investigate whether par-3 partitioning defective 3 homolog (C. elegans) (PARD3) single nucleotide polymorphisms (SNPs) are associated with schizophrenia. A total of 204 Korean schizophrenic patients [117 male, 41.1±9.6 years (mean age ± SD); 87 female, 42.6±11.5] and 351 control subjects (170 male, 43.8±6.6 years; 181 female, 44.2±5.8) were enrolled. We genotyped nine SNPs of the PARD3 gene [rs7075263 (intron), rs10827392 (intron), rs773970 (intron), rs2252655 (intron), rs10763984 (intron), rs3781128 (Ser889Ser), rs1936429 (intron), rs671228 (intron) and rs16935163 (intron)]. Genotypes of PARD3 polymorphisms were evaluated by direct sequencing. We used SNPStats, SPSS 18.0 and Haploview 4.2 software for analysis of genetic data. Multiple logistic regression models were used to calculate the odds ratio (OR), 95% confidence interval (CI), and corresponding p‑values (p), controlling for age and gender as covariables. Allele frequencies of the PARD3 SNPs were significantly associated with schizophrenia (rs3781128, p=0.041; rs1936429, p=0.030; rs671228, p=0.028). Certain genotype frequencies of the PARD3 SNPs also showed significant associations with schizophrenia (p<0.05, rs7075263, rs773970, rs2252655, rs10763984, rs3781128, rs1936429, rs16935163). To the best of our knowledge, this is the first report showing that PARD3 is associated with susceptibility to schizophrenia in a Korean population. In conclusion, our findings suggest that PARD3 may contribute to genetic susceptibility to schizophrenia.
View References
|
1.
|
Kleinman JE, Law AJ, Lipska BK, et al:
Genetic neuropathology of schizophrenia: new approaches to an old
question and new uses for postmortem human brains. Biol Psychiatry.
69:140–145. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
2.
|
Faludi G and Mirnics K: Synaptic changes
in the brain of subjects with schizophrenia. Int J Dev Neurosci.
29:305–309. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
3.
|
Mitterauer B: Loss of function of glial
gap junctions may cause severe cognitive impairments in
schizophrenia. Med Hypotheses. 73:393–397. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
4.
|
Sun ZY, Wei J, Xie L, et al: The CLDN5
locus may be involved in the vulnerability to schizophrenia. Eur
Psychiatry. 19:354–357. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
5.
|
Barrett JC, Fry B, Maller J, et al:
Haploview: analysis and visualization of LD and haplotype maps.
Bioinformatics. 21:263–265. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
6.
|
Mizuno K, Suzuki A, Hirose T, et al:
Self-association of PAR-3-mediated by the conserved N-terminal
domain contributes to the development of epithelial tight
junctions. J Biol Chem. 278:31240–31250. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
7.
|
Zen K, Yasui K, Gen Y, et al: Defective
expression of polarity protein PAR-3 gene (PARD3) in esophageal
squamous cell carcinoma. Oncogene. 28:2910–2918. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
8.
|
Chan JR, Jolicoeur C, Yamauchi J, et al:
The polarity protein Par-3 directly interacts with p75NTR to
regulate myelination. Science. 314:832–836. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
9.
|
Chen X and Macara IG: Par-3 controls tight
junction assembly through the Rac exchange factor Tiam1. Nat Cell
Biol. 7:262–269. 2005. View
Article : Google Scholar : PubMed/NCBI
|
|
10.
|
Willott E, Balda MS, Fanning AS, et al:
The tight junction protein ZO-1 is homologous to the Drosophila
discs – large tumor suppressor protein of septate junctions. Proc
Natl Acad Sci USA. 90:7834–7838. 1993.
|
|
11.
|
Mino A, Ohtsuka T, Inoue E, et al:
Membrane-associated guanylate kinase with inverted orientation
(MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1)
as a scaffolding molecule for Rap small G protein GDP/GTP exchange
protein at tight junctions. Genes Cells. 5:1009–1016. 2000.
View Article : Google Scholar
|
|
12.
|
Biederer T, Sara Y, Mozhayeva M, et al:
SynCAM, a synaptic adhesion molecule that drives synapse assembly.
Science. 297:1525–1531. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
13.
|
Ebnet K, Aurrand-Lions M, Kuhn A, et al:
The junctional adhesion molecule (JAM) family members JAM-2 and
JAM-3 associate with the cell polarity protein PAR-3: a possible
role for JAMs in endothelial cell polarity. J Cell Sci.
116:3879–3891. 2003. View Article : Google Scholar : PubMed/NCBI
|
